J
Joseph Kuchling
Researcher at Humboldt University of Berlin
Publications - 45
Citations - 1919
Joseph Kuchling is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Multiple sclerosis & Neuromyelitis optica. The author has an hindex of 16, co-authored 37 publications receiving 1379 citations. Previous affiliations of Joseph Kuchling include Max Delbrück Center for Molecular Medicine & Technische Universität München.
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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Marius Ringelstein,Corinna Trebst,Alexander Winkelmann,Alexander Schwarz,Mathias Buttmann,Hanna Zimmermann,Joseph Kuchling,Diego Franciotta,Marco Capobianco,Eberhard Siebert,Carsten Lukas,Mirjam Korporal-Kuhnke,Jürgen Haas,Kai Fechner,Alexander U. Brandt,Kathrin Schanda,Orhan Aktas,Friedemann Paul,Markus Reindl,Brigitte Wildemann +29 more
TL;DR: The predominantly relapsing and often severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal.
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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin.
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Corinna Trebst,Marius Ringelstein,Orhan Aktas,Alexander Winkelmann,Mathias Buttmann,Alexander Schwarz,Hanna Zimmermann,Alexander U. Brandt,Diego Franciotta,Marco Capobianco,Joseph Kuchling,Jürgen Haas,Mirjam Korporal-Kuhnke,Soeren Thue Lillevang,Kai Fechner,Kathrin Schanda,Friedemann Paul,Brigitte Wildemann,Markus Reindl +28 more
TL;DR: This is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA and finds MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS.
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Microstructural visual system changes in AQP4-antibody-seropositive NMOSD.
Frederike C. Oertel,Joseph Kuchling,Hanna Zimmermann,Claudia Chien,Felix Schmidt,Benjamin Knier,Judith Bellmann-Strobl,Thomas Korn,Michael Scheel,Alexander Klistorner,Klemens Ruprecht,Friedemann Paul,Alexander U. Brandt +12 more
TL;DR: Patients with AQP4-ab–seropositive NMOSD without a history of ON have microstructural changes in the afferent visual system, and the localization of retinal changes around the Müller-cell rich fovea supports a retinal astrocytopathy.
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Uncovering convolutional neural network decisions for diagnosing multiple sclerosis on conventional MRI using layer-wise relevance propagation.
Fabian Eitel,Emily Soehler,Judith Bellmann-Strobl,Alexander U. Brandt,Klemens Ruprecht,René M. Giess,Joseph Kuchling,Susanna Asseyer,Martin Weygandt,John-Dylan Haynes,Michael Scheel,Friedemann Paul,Kerstin Ritter +12 more
TL;DR: In this paper, a transparent deep learning framework relying on 3D convolutional neural networks (CNNs) and layer-wise relevance propagation (LRP) was proposed for diagnosing multiple sclerosis (MS), the most widespread autoimmune neuroinflammatory disease.
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Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density
Janine Mikolajczak,Hanna Zimmermann,Ahmad Kheirkhah,Ella Maria Kadas,Timm Oberwahrenbrock,Rodrigo T Muller,Aiai Ren,Joseph Kuchling,Holger Dietze,Harald Prüss,Friedemann Paul,Pedram Hamrah,Alexander U. Brandt +12 more
TL;DR: Reduced total nerve fibre density was associated with worse clinical severity but not with previous clinical trigeminal symptoms, retinal neuro-axonal damage, visual acuity or disease duration.