F
Florence Pache
Researcher at Charité
Publications - 44
Citations - 3671
Florence Pache is an academic researcher from Charité. The author has contributed to research in topics: Neuromyelitis optica & Optic neuritis. The author has an hindex of 24, co-authored 39 publications receiving 2754 citations. Previous affiliations of Florence Pache include Humboldt University of Berlin & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Marius Ringelstein,Corinna Trebst,Alexander Winkelmann,Alexander Schwarz,Mathias Buttmann,Hanna Zimmermann,Joseph Kuchling,Diego Franciotta,Marco Capobianco,Eberhard Siebert,Carsten Lukas,Mirjam Korporal-Kuhnke,Jürgen Haas,Kai Fechner,Alexander U. Brandt,Kathrin Schanda,Orhan Aktas,Friedemann Paul,Markus Reindl,Brigitte Wildemann +29 more
TL;DR: The predominantly relapsing and often severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal.
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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin.
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Corinna Trebst,Marius Ringelstein,Orhan Aktas,Alexander Winkelmann,Mathias Buttmann,Alexander Schwarz,Hanna Zimmermann,Alexander U. Brandt,Diego Franciotta,Marco Capobianco,Joseph Kuchling,Jürgen Haas,Mirjam Korporal-Kuhnke,Soeren Thue Lillevang,Kai Fechner,Kathrin Schanda,Friedemann Paul,Brigitte Wildemann,Markus Reindl +28 more
TL;DR: This is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA and finds MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS.
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Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses.
Ingo Kleiter,Anna Gahlen,Nadja Borisow,Katrin Fischer,Klaus-Dieter Wernecke,Brigitte Wegner,Kerstin Hellwig,Florence Pache,Klemens Ruprecht,Joachim Havla,Markus Krumbholz,Tania Kümpfel,Orhan Aktas,Hans-Peter Hartung,Marius Ringelstein,Christian Geis,Christoph Kleinschnitz,Achim Berthele,Bernhard Hemmer,Klemens Angstwurm,Jan-Patrick Stellmann,Simon Schuster,Martin Stangel,Florian Lauda,Hayrettin Tumani,Christoph Mayer,Lena Zeltner,Ulf Ziemann,Ralf A. Linker,Matthias Schwab,Martin Marziniak,Florian Then Bergh,Ulrich Hofstadt-van Oy,Oliver Neuhaus,Alexander Winkelmann,Wael Marouf,Jürgen H. Faiss,Brigitte Wildemann,Friedemann Paul,Sven Jarius,Corinna Trebst +40 more
TL;DR: The frequency, sequence, and efficacy of therapies used for NMO attacks are analyzed and it is shown that certain therapies are more effective than others in cases of severe N MO attacks.
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The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.
Martin Witzenrath,Florence Pache,Daniel Lorenz,Uwe Koppe,Birgitt Gutbier,Christoph Tabeling,Katrin Reppe,Karolin Meixenberger,Anca Dorhoi,Jiangtao Ma,Ashleigh Holmes,George Trendelenburg,Markus M. Heimesaat,Stefan Bereswill,Mark van der Linden,Jürg Tschopp,Timothy J. Mitchell,Norbert Suttorp,Bastian Opitz +18 more
TL;DR: The inflammasome pathway is protective in pneumonia caused by pneumococci expressing hemolytic toxin but is not activated by clinically important pneumococcal sequence types causing invasive disease, and indicates that a virulence factor polymorphism may substantially affect the recognition of bacteria by the innate immune system.
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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients
Florence Pache,Hanna Zimmermann,Janine Mikolajczak,Sophie Schumacher,Anna Lacheta,Frederike C. Oertel,Judith Bellmann-Strobl,Judith Bellmann-Strobl,Sven Jarius,Brigitte Wildemann,Markus Reindl,Amy Waldman,Kerstin Soelberg,Nasrin Asgari,Marius Ringelstein,Orhan Aktas,Nikolai Gross,Mathias Buttmann,Thomas Ach,Klemens Ruprecht,Friedemann Paul,Friedemann Paul,Alexander U. Brandt +22 more
TL;DR: Retinal neuro-axonal damage and visual impairment after ON in MOG-IgG-positive patients are as severe as in AQP4-IGG- positive NMOSD patients.