M
Mirjam Korporal-Kuhnke
Researcher at University Hospital Heidelberg
Publications - 16
Citations - 1531
Mirjam Korporal-Kuhnke is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Multiple sclerosis & Myelitis. The author has an hindex of 10, co-authored 13 publications receiving 1105 citations. Previous affiliations of Mirjam Korporal-Kuhnke include Boston Children's Hospital & Heidelberg University.
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Journal ArticleDOI
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Marius Ringelstein,Corinna Trebst,Alexander Winkelmann,Alexander Schwarz,Mathias Buttmann,Hanna Zimmermann,Joseph Kuchling,Diego Franciotta,Marco Capobianco,Eberhard Siebert,Carsten Lukas,Mirjam Korporal-Kuhnke,Jürgen Haas,Kai Fechner,Alexander U. Brandt,Kathrin Schanda,Orhan Aktas,Friedemann Paul,Markus Reindl,Brigitte Wildemann +29 more
TL;DR: The predominantly relapsing and often severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal.
Journal ArticleDOI
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin.
Sven Jarius,Klemens Ruprecht,Ingo Kleiter,Nadja Borisow,Nasrin Asgari,Kalliopi Pitarokoili,Florence Pache,Oliver Stich,Lena-Alexandra Beume,Martin W. Hümmert,Corinna Trebst,Marius Ringelstein,Orhan Aktas,Alexander Winkelmann,Mathias Buttmann,Alexander Schwarz,Hanna Zimmermann,Alexander U. Brandt,Diego Franciotta,Marco Capobianco,Joseph Kuchling,Jürgen Haas,Mirjam Korporal-Kuhnke,Soeren Thue Lillevang,Kai Fechner,Kathrin Schanda,Friedemann Paul,Brigitte Wildemann,Markus Reindl +28 more
TL;DR: This is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA and finds MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS.
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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome.
Sven Jarius,Ingo Kleiter,Klemens Ruprecht,Nasrin Asgari,Kalliopi Pitarokoili,Nadja Borisow,Martin W. Hümmert,Corinna Trebst,Florence Pache,Alexander Winkelmann,Lena Beume,Marius Ringelstein,Oliver Stich,Orhan Aktas,Mirjam Korporal-Kuhnke,Alexander Schwarz,Carsten Lukas,Jürgen Haas,Kai Fechner,Mathias Buttmann,Judith Bellmann-Strobl,Hanna Zimmermann,Alexander U. Brandt,Diego Franciotta,Kathrin Schanda,Friedemann Paul,Markus Reindl,Brigitte Wildemann +27 more
TL;DR: Brainstem involvement is present in around one third of MOG-IgG-positive patients with ON and/or myelitis, and is associated with a more aggressive general disease course.
Journal ArticleDOI
Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients
Sven Jarius,Hannah L. Pellkofer,Nadja Siebert,Mirjam Korporal-Kuhnke,Martin W. Hümmert,Marius Ringelstein,Paulus S. Rommer,Ilya Ayzenberg,Klemens Ruprecht,Luisa Klotz,Nasrin Asgari,Tobias Zrzavy,Romana Höftberger,Rafik Tobia,Mathias Buttmann,Kai Fechner,Kathrin Schanda,Martin S. Weber,Susanna Asseyer,Jürgen Haas,Christian Lechner,Ingo Kleiter,Orhan Aktas,Corinna Trebst,Kevin Rostasy,Markus Reindl,Tania Kümpfel,Friedemann Paul,Brigitte Wildemann +28 more
TL;DR: MOG-IgG-positive EM is characterized by CSF features that are distinct from those in multiple sclerosis, important for the differential diagnosis of MS and MOG-EM and add to the understanding of the immunopathogenesis of this newly described autoimmune disease.
Journal ArticleDOI
Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography.
Johann M E Jende,Gesa H. Hauck,Gesa H. Hauck,Ricarda Diem,Markus Weiler,Sabine Heiland,Brigitte Wildemann,Mirjam Korporal-Kuhnke,Wolfgang Wick,John M. Hayes,Johannes Pfaff,Mirko Pham,Martin Bendszus,Jennifer Kollmer +13 more
TL;DR: To detect and quantify peripheral nerve lesions in multiple sclerosis (MS) by magnetic resonance neurography (MRN) by using X-ray diffraction analysis.