J
Joseph L. Mann
Researcher at Stanford University
Publications - 21
Citations - 381
Joseph L. Mann is an academic researcher from Stanford University. The author has contributed to research in topics: Insulin & Self-healing hydrogels. The author has an hindex of 8, co-authored 18 publications receiving 207 citations.
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Journal ArticleDOI
Supramolecular polymeric biomaterials
TL;DR: This review examines the relationship between supramolecular crosslink chemistry and biomedically relevant macroscopic properties and describes how these properties are currently leveraged in the development of materials for drug delivery, immunology, regenerative medicine, and 3D-bioprinting.
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A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs.
Caitlin L. Maikawa,Anton A. A. Smith,Anton A. A. Smith,Lei Zou,Gillie A. Roth,Emily C. Gale,Lyndsay M. Stapleton,Sam W. Baker,Joseph L. Mann,Anthony C. Yu,Santiago Correa,Abigail K. Grosskopf,Celine Liong,Catherine M. Meis,Doreen Chan,Megan L. Troxell,David M. Maahs,Bruce A. Buckingham,Matthew J. Webber,Eric A. Appel +19 more
TL;DR: The co-administration of supramolecularly stabilized insulin and pramlintide better mimics the endogenous kinetics of co-secreted insulin and amylin, and holds promise as a dual-hormone replacement therapy.
Journal ArticleDOI
An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients.
Joseph L. Mann,Caitlin L. Maikawa,Anton A. A. Smith,Anton A. A. Smith,Abigail K. Grosskopf,Sam W. Baker,Gillie A. Roth,Catherine M. Meis,Emily C. Gale,Celine Liong,Santiago Correa,Doreen Chan,Lyndsay M. Stapleton,Anthony C. Yu,Ben Muir,Shaun C. Howard,Almar Postma,Eric A. Appel +17 more
TL;DR: High-throughput–controlled radical polymerization techniques are implemented to generate a large library of acrylamide carrier/dopant copolymer (AC/DC) excipients designed to reduce insulin aggregation and improve pharmacokinetics, making UFAL a promising candidate for improving glucose control and reducing burden for patients with diabetes.
Journal ArticleDOI
Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues.
Caitlin L. Maikawa,Anton A. A. Smith,Lei Zou,Catherine M. Meis,Joseph L. Mann,Matthew J. Webber,Eric A. Appel +6 more
TL;DR: A novel excipient for the supramolecular PEGylation of insulin analogues, including aspart and lispro, is exploited to enhance the stability and maximize the prevalence of insulin monomers in formulation to reduce the risk of post‐prandial hypoglycemia in the treatment of diabetes.
Journal ArticleDOI
Lipid Nanodiscs via Ordered Copolymers
Anton A. A. Smith,Anton A. A. Smith,Henriette Elisabeth Autzen,Henriette Elisabeth Autzen,Bryan Faust,Joseph L. Mann,Benjamin W. Muir,Shaun C. Howard,Almar Postma,Andrew J. Spakowitz,Yifan Cheng,Yifan Cheng,Eric A. Appel +12 more
TL;DR: A highly alternating copolymer composed of acrylic acid and styrene is developed by taking advantage of the fundamental reactivity ratios of these monomers to provide a new chemical platform for structural and functional characterization of integral membrane proteins in native nanodiscs.