Joseph L. Mann

TL;DR: This review examines the relationship between supramolecular crosslink chemistry and biomedically relevant macroscopic properties and describes how these properties are currently leveraged in the development of materials for drug delivery, immunology, regenerative medicine, and 3D-bioprinting.

TL;DR: The co-administration of supramolecularly stabilized insulin and pramlintide better mimics the endogenous kinetics of co-secreted insulin and amylin, and holds promise as a dual-hormone replacement therapy.

TL;DR: High-throughput–controlled radical polymerization techniques are implemented to generate a large library of acrylamide carrier/dopant copolymer (AC/DC) excipients designed to reduce insulin aggregation and improve pharmacokinetics, making UFAL a promising candidate for improving glucose control and reducing burden for patients with diabetes.

TL;DR: A novel excipient for the supramolecular PEGylation of insulin analogues, including aspart and lispro, is exploited to enhance the stability and maximize the prevalence of insulin monomers in formulation to reduce the risk of post‐prandial hypoglycemia in the treatment of diabetes.

TL;DR: A highly alternating copolymer composed of acrylic acid and styrene is developed by taking advantage of the fundamental reactivity ratios of these monomers to provide a new chemical platform for structural and functional characterization of integral membrane proteins in native nanodiscs.