Joseph Loscalzo

TL;DR: The technology described in this article is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of such agents for, e.g. to treat hypertension.

TL;DR: The clotting of blood in response to injury is a primordial\ but highly efficient and complex affair, the analysis of which remains a challenge.

TL;DR: The use of S-nitroso-lipoprotein for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle and to deliver nitric oxide in its most bioactive form in order to achieve the effects described above as discussed by the authors.

TL;DR: A case of superior mesenteric artery dissection prompting clinical genetic testing to investigate the underlying mechanisms of the vasculopathy is presented.

TL;DR: In this paper , the meaning of research reproducibility and the factors that contribute to irreproducibility in biomedical research have been discussed, as well as potential interventions to counter the current level of irreducibility aimed at increasing the efficiency and impact of society's substantial and critically important investment in bioscience research.