J
Joseph Loscalzo
Researcher at Brigham and Women's Hospital
Publications - 875
Citations - 79338
Joseph Loscalzo is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Nitric oxide & Platelet. The author has an hindex of 129, co-authored 828 publications receiving 71573 citations. Previous affiliations of Joseph Loscalzo include Veterans Health Administration & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
Gilbert R. Upchurch,George N. Welch,Attila J. Fabian,Jane E. Freedman,Joseph L. Johnson,John F. Keaney,Joseph Loscalzo +6 more
TL;DR: It is shown that Hcy treatment of bovine aortic endothelial cells leads to a dose-dependent decrease in NO x independent of endothelial nitric-oxide synthase activity or protein levels and nos3 transcription, suggesting that HCy affects the bioavailability of NO, not its production.
Journal ArticleDOI
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility
Tanja Zeller,Philipp S. Wild,Silke Szymczak,Maxime Rotival,Arne Schillert,Raphaële Castagné,Seraya Maouche,Marine Germain,Karl J. Lackner,Heidi Rossmann,Medea S. Eleftheriadis,C. Sinning,Renate B. Schnabel,Edith Lubos,Detlev Mennerich,Werner Rust,Claire Perret,Carole Proust,Viviane Nicaud,Joseph Loscalzo,Norbert Hubner,David-Alexandre Trégouët,Thomas Münzel,Andreas Ziegler,Laurence Tiret,Stefan Blankenberg,François Cambien +26 more
TL;DR: This study demonstrates that the monocyte transcriptome is a potent integrator of genetic and non-genetic influences of relevance for disease pathophysiology and risk assessment.
Journal ArticleDOI
Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.
Benjamin Gaston,John J. Reilly,Jeffrey M. Drazen,James C. Fackler,Pranai Ramdev,Derrick R. Arnelle,Mark E. Mullins,David J. Sugarbaker,Cynthia B. E. Chee,David J. Singel,Joseph Loscalzo,Jonathan S. Stamler +11 more
TL;DR: S-nitrosothiols (RS-NO), predominantly the adduct with glutathione, are present at nano- to micromolar concentrations in the airways of normal subjects and that their levels vary in different human pathophysiologic states, suggesting an important role for NO.
Journal ArticleDOI
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2
Stephen Y. Chan,Ying Yi Zhang,Ying Yi Zhang,Craig Hemann,Christopher E Mahoney,Christopher E Mahoney,Jay L. Zweier,Joseph Loscalzo,Joseph Loscalzo +8 more
TL;DR: Important mechanistic connections among microRNA, iron-sulfur cluster biology, hypoxia, and mitochondrial function are identified, with broad implications for cellular metabolism and adaptation to cellular stress.