J
Joseph Loscalzo
Researcher at Brigham and Women's Hospital
Publications - 875
Citations - 79338
Joseph Loscalzo is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Nitric oxide & Platelet. The author has an hindex of 129, co-authored 828 publications receiving 71573 citations. Previous affiliations of Joseph Loscalzo include Veterans Health Administration & University of California, Los Angeles.
Papers
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Posted ContentDOI
Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations
Feixiong Cheng,Feixiong Cheng,Feixiong Cheng,Junfei Zhao,Yang Wang,Weiqiang Lu,Zehui Liu,Yadi Zhou,William R. Martin,Rui-Sheng Wang,Jin Huang,Tong Hao,Hong Yue,Jing Ma,Yuan Hou,Jessica A. Castrillon,Jiansong Fang,Justin D. Lathia,Justin D. Lathia,Ruth A. Keri,Felice C. Lightstone,Elliott M. Antman,Raul Rabadan,David E. Hill,Charis Eng,Marc Vidal,Joseph Loscalzo +26 more
TL;DR: This study investigates at large-scale the effects of network perturbations caused by disease mutations within the human three-dimensional (3D), structurally-resolved macromolecular interactome and shows that disease-associated germline mutations are significantly enriched in sequences encoding protein-protein interfaces compared to mutations identified in healthy subjects from the 1000 Genomes and ExAC projects.
Journal ArticleDOI
Validation of network medicine interactomes: From patients to a human hepatocyte-like model
F. Grassi,Daniele Dall'Olio,Osman Ahmed,C Sala,Matteo Bersanelli,Camilla Pramfalk,Paolo Garagnani,Enrico Petrillo,Joseph Loscalzo,Matteo Pedrelli,Parini Parini +10 more
TL;DR: In this paper , the effects of atorvastatin (5μM) and ezetimibe (10 mg/day) alone or in combination on hepG2-only-HepG2 cells were investigated.
Book ChapterDOI
Systems Chemical Biology: Integrating Medicinal Chemistry and Systems Biology for Drug Discovery
Rui-Sheng Wang,Joseph Loscalzo +1 more
TL;DR: The methodologies of systems chemical biology are reviewed and their impact on drug discovery and development is discussed and it is suggested that these approaches not only offer new unique insights into biological systems but also have important applications in biomedicine.