J
Joseph Marcotrigiano
Researcher at Center for Advanced Biotechnology and Medicine
Publications - 40
Citations - 3095
Joseph Marcotrigiano is an academic researcher from Center for Advanced Biotechnology and Medicine. The author has contributed to research in topics: RNA & Hepatitis C virus. The author has an hindex of 22, co-authored 40 publications receiving 2667 citations. Previous affiliations of Joseph Marcotrigiano include Rutgers University & Rockefeller University.
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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
TL;DR: This work identifies the polyuridine motif of the HCV genome 3′ non-translated region and its replication intermediate as the PAMP substrate of RIG-I, and shows that this and similar homopolyuridine or homopolyriboadenine motifs present in the genomes of RNA viruses are the chief feature of Rig-I recognition and immune triggering in human and murine cells.
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Structural basis of RNA recognition and activation by innate immune receptor RIG-I
Fuguo Jiang,Anand Ramanathan,Matthew T. Miller,Guo-Qing Tang,Michael Gale,Smita S. Patel,Joseph Marcotrigiano +6 more
TL;DR: A detailed view of the role of helicase in dsRNA recognition, the synergy between the RD and the helicase for RNA binding and the organization of full-length RIG-I bound to ds RNA is provided, and evidence of a conformational change upon RNA binding is provided.
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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
Barzin Y. Nabet,Yu Qiu,Jacob E. Shabason,Tony J. Wu,Taewon Yoon,Brian C. Kim,Joseph L. Benci,Angela DeMichele,Julia Tchou,Joseph Marcotrigiano,Andy J. Minn +10 more
TL;DR: Results demonstrate that regulation of RNA unshielding couples stromal activation with deployment of RNA DAMPs that promote aggressive features of cancer.
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Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2
Abdul Ghafoor Khan,Jillian Whidby,Matthew T. Miller,Hannah Scarborough,Alexandra V. Zatorski,Alicja M. Cygan,Aryan A. Price,Samantha A. Yost,Caitlin Bohannon,Joshy Jacob,Arash Grakoui,Joseph Marcotrigiano +11 more
TL;DR: Solution-based studies demonstrate that the full-length E2 ectodomain has a similar globular architecture and does not undergo significant conformational or oligomeric rearrangements on exposure to low pH, and provides unprecedented insights into HCV entry.
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Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Swapnil C. Devarkar,Chen Wang,Matthew T. Miller,Anand Ramanathan,Fuguo Jiang,Abdul Ghafoor Khan,Smita S. Patel,Joseph Marcotrigiano +7 more
TL;DR: It is shown that RIG-I accommodates the m7G base while maintaining the 5′ppp contacts and can recognize Cap-0 RNAs but not Cap-1, and a single H830A mutation restores both high-affinity binding and signaling activity with 2′-O-methylated dsRNAs.