J
Joseph R. Ledsam
Researcher at Google
Publications - 43
Citations - 6480
Joseph R. Ledsam is an academic researcher from Google. The author has contributed to research in topics: Computer science & Segmentation. The author has an hindex of 19, co-authored 42 publications receiving 3791 citations. Previous affiliations of Joseph R. Ledsam include University of Leeds.
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Journal ArticleDOI
Clinically applicable deep learning for diagnosis and referral in retinal disease
Jeffrey De Fauw,Joseph R. Ledsam,Bernardino Romera-Paredes,Stanislav Nikolov,Nenad Tomasev,Sam Blackwell,Harry Askham,Xavier Glorot,Brendan O'Donoghue,Daniel Visentin,George van den Driessche,Balaji Lakshminarayanan,Clemens Meyer,Faith Mackinder,Simon Bouton,Kareem Ayoub,Reena Chopra,Dominic King,Alan Karthikesalingam,Cian Hughes,Rosalind Raine,Julian Hughes,Dawn A Sim,Catherine A Egan,Adnan Tufail,Hugh Montgomery,Demis Hassabis,Geraint Rees,Trevor Back,Peng T. Khaw,Mustafa Suleyman,Julien Cornebise,Pearse A. Keane,Olaf Ronneberger +33 more
TL;DR: A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.
Journal ArticleDOI
International evaluation of an AI system for breast cancer screening.
Scott Mayer McKinney,Marcin Sieniek,Varun Godbole,Jonathan Godwin,Natasha Antropova,Hutan Ashrafian,Trevor Back,Mary Chesus,Greg C. Corrado,Ara Darzi,Mozziyar Etemadi,Florencia Garcia-Vicente,Fiona J. Gilbert,Mark D. Halling-Brown,Demis Hassabis,Sunny Jansen,Alan Karthikesalingam,Christopher Kelly,Dominic King,Joseph R. Ledsam,David S. Melnick,Hormuz Mostofi,Lily Peng,Joshua J. Reicher,Bernardino Romera-Paredes,Richard Sidebottom,Mustafa Suleyman,Daniel Tse,Kenneth C. Young,Jeffrey De Fauw,Shravya Shetty +30 more
TL;DR: A robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening and using a combination of AI and human inputs could help to improve screening efficiency.
Journal ArticleDOI
A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis
Xiaoxuan Liu,Livia Faes,Aditya Kale,Siegfried K Wagner,Dun Jack Fu,Alice Bruynseels,Thushika Mahendiran,Gabriella Moraes,Mohith Shamdas,Christoph Kern,Christoph Kern,Joseph R. Ledsam,Martin Schmid,Konstantinos Balaskas,Konstantinos Balaskas,Eric J. Topol,Lucas M. Bachmann,Pearse A. Keane,Alastair K Denniston +18 more
TL;DR: A major finding of the review is that few studies presented externally validated results or compared the performance of deep learning models and health-care professionals using the same sample, which limits reliable interpretation of the reported diagnostic accuracy.
Journal ArticleDOI
A clinically applicable approach to continuous prediction of future acute kidney injury
Nenad Tomasev,Xavier Glorot,Jack W. Rae,Michal Zielinski,Harry Askham,Andre Saraiva,Anne Mottram,Clemens Meyer,Suman V. Ravuri,Ivan Protsyuk,Alistair Connell,Cian Hughes,Alan Karthikesalingam,Julien Cornebise,Hugh Montgomery,Geraint Rees,Chris Laing,Clifton R. Baker,Kelly S. Peterson,Ruth M. Reeves,Demis Hassabis,Dominic King,Mustafa Suleyman,Trevor Back,Christopher Nielson,Christopher Nielson,Joseph R. Ledsam,Shakir Mohamed +27 more
TL;DR: A deep learning approach that predicts the risk of acute kidney injury and provides confidence assessments and a list of the clinical features that are most salient to each prediction, alongside predicted future trajectories for clinically relevant blood tests are developed.
Posted Content
A Probabilistic U-Net for Segmentation of Ambiguous Images
Simon A. A. Kohl,Bernardino Romera-Paredes,Clemens Meyer,Jeffrey De Fauw,Joseph R. Ledsam,Klaus H. Maier-Hein,S. M. Ali Eslami,Danilo Jimenez Rezende,Olaf Ronneberger +8 more
TL;DR: A generative segmentation model based on a combination of a U-Net with a conditional variational autoencoder that is capable of efficiently producing an unlimited number of plausible hypotheses and reproduces the possible segmentation variants as well as the frequencies with which they occur significantly better than published approaches.