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Sam Blackwell
Publications - 7
Citations - 3568
Sam Blackwell is an academic researcher. The author has contributed to research in topics: Segmentation & Deep learning. The author has an hindex of 5, co-authored 7 publications receiving 1690 citations.
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Journal ArticleDOI
Clinically applicable deep learning for diagnosis and referral in retinal disease
Jeffrey De Fauw,Joseph R. Ledsam,Bernardino Romera-Paredes,Stanislav Nikolov,Nenad Tomasev,Sam Blackwell,Harry Askham,Xavier Glorot,Brendan O'Donoghue,Daniel Visentin,George van den Driessche,Balaji Lakshminarayanan,Clemens Meyer,Faith Mackinder,Simon Bouton,Kareem Ayoub,Reena Chopra,Dominic King,Alan Karthikesalingam,Cian Hughes,Rosalind Raine,Julian Hughes,Dawn A Sim,Catherine A Egan,Adnan Tufail,Hugh Montgomery,Demis Hassabis,Geraint Rees,Trevor Back,Peng T. Khaw,Mustafa Suleyman,Julien Cornebise,Pearse A. Keane,Olaf Ronneberger +33 more
TL;DR: A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.
Posted ContentDOI
Protein complex prediction with AlphaFold-Multimer
Richard Evans,Michael J. O'Neill,Alexander Pritzel,Natasha Antropova,Andrew W. Senior,Tim Green,Augustin Žídek,Russell Bates,Sam Blackwell,Jason Yim,Olaf Ronneberger,Sebastian Bodenstein,Michal Zielinski,Alex Bridgland,Anna Potapenko,Andrew Cowie,Kathryn Tunyasuvunakool,R. D. Jain,Ellen Clancy,Pushmeet Kohli,John M. Jumper,Demis Hassabis +21 more
TL;DR: In this article, an AlphaFold model trained specifically for multimeric inputs of known stoichiometry was proposed, which significantly increases the accuracy of predicted multimimeric interfaces over input-adapted single-chain AlphaFolds.
Posted Content
Massively Parallel Methods for Deep Reinforcement Learning
Arun Nair,Praveen Deepak Srinivasan,Sam Blackwell,Cagdas Alcicek,Rory Fearon,Alessandro De Maria,Vedavyas Panneershelvam,Mustafa Suleyman,Charles Beattie,Stig Petersen,Shane Legg,Volodymyr Mnih,Koray Kavukcuoglu,David Silver +13 more
TL;DR: This work presents the first massively distributed architecture for deep reinforcement learning, using a distributed neural network to represent the value function or behaviour policy, and a distributed store of experience to implement the Deep Q-Network algorithm.
Posted Content
Deep learning to achieve clinically applicable segmentation of head and neck anatomy for radiotherapy
Stanislav Nikolov,Sam Blackwell,R. Mendes,Jeffrey De Fauw,Clemens Meyer,Cian Hughes,Harry Askham,Bernardino Romera-Paredes,Alan Karthikesalingam,Carlton Chu,Dawn Carnell,Cheng Boon,Derek D'Souza,S. Moinuddin,Kevin Sullivan,Hugh Montgomery,Geraint Rees,Ricky A. Sharma,Mustafa Suleyman,Trevor Back,Joseph R. Ledsam,Olaf Ronneberger +21 more
TL;DR: A 3D U-Net architecture that achieves performance similar to experts in delineating a wide range of head and neck OARs is demonstrated that could improve the effectiveness of radiotherapy pathways.
Journal ArticleDOI
Clinically Applicable Segmentation of Head and Neck Anatomy for Radiotherapy: Deep Learning Algorithm Development and Validation Study
Stanislav Nikolov,Sam Blackwell,Alexei Zverovitch,R. Mendes,Michelle Livne,Jeffrey De Fauw,Yojan Patel,Clemens Meyer,Harry Askham,Bernadino Romera-Paredes,Christopher Kelly,Alan Karthikesalingam,Carlton Chu,Dawn Carnell,Cheng Boon,Derek D'Souza,S. Moinuddin,Bethany Garie,Yasmin McQuinlan,Sarah Ireland,Kiarna Hampton,Krystle Fuller,Hugh Montgomery,Geraint Rees,Mustafa Suleyman,Trevor Back,Cían Owen Hughes,Joseph R. Ledsam,Olaf Ronneberger +28 more
TL;DR: In this article, a 3D U-Net architecture was used to segment head and neck organs at risk commonly segmented in clinical practice, and the model was trained on a data set of 663 deidentified computed tomography scans acquired in routine clinical practice and with both segmentations taken from clinical practices and segmentations created by experienced radiographers.