P
Pearse A. Keane
Researcher at Moorfields Eye Hospital
Publications - 264
Citations - 10653
Pearse A. Keane is an academic researcher from Moorfields Eye Hospital. The author has contributed to research in topics: Medicine & Macular degeneration. The author has an hindex of 39, co-authored 211 publications receiving 6367 citations. Previous affiliations of Pearse A. Keane include UCL Institute of Ophthalmology & University Hospitals Birmingham NHS Foundation Trust.
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Journal ArticleDOI
Clinically applicable deep learning for diagnosis and referral in retinal disease
Jeffrey De Fauw,Joseph R. Ledsam,Bernardino Romera-Paredes,Stanislav Nikolov,Nenad Tomasev,Sam Blackwell,Harry Askham,Xavier Glorot,Brendan O'Donoghue,Daniel Visentin,George van den Driessche,Balaji Lakshminarayanan,Clemens Meyer,Faith Mackinder,Simon Bouton,Kareem Ayoub,Reena Chopra,Dominic King,Alan Karthikesalingam,Cian Hughes,Rosalind Raine,Julian Hughes,Dawn A Sim,Catherine A Egan,Adnan Tufail,Hugh Montgomery,Demis Hassabis,Geraint Rees,Trevor Back,Peng T. Khaw,Mustafa Suleyman,Julien Cornebise,Pearse A. Keane,Olaf Ronneberger +33 more
TL;DR: A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.
Journal ArticleDOI
A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis
Xiaoxuan Liu,Livia Faes,Aditya Kale,Siegfried K Wagner,Dun Jack Fu,Alice Bruynseels,Thushika Mahendiran,Gabriella Moraes,Mohith Shamdas,Christoph Kern,Christoph Kern,Joseph R. Ledsam,Martin Schmid,Konstantinos Balaskas,Konstantinos Balaskas,Eric J. Topol,Lucas M. Bachmann,Pearse A. Keane,Alastair K Denniston +18 more
TL;DR: A major finding of the review is that few studies presented externally validated results or compared the performance of deep learning models and health-care professionals using the same sample, which limits reliable interpretation of the reported diagnostic accuracy.
Journal ArticleDOI
Artificial intelligence and deep learning in ophthalmology
Daniel Shu Wei Ting,Louis R. Pasquale,Lily Peng,John P. Campbell,Aaron Y. Lee,Rajiv Raman,Gavin Tan,Leopold Schmetterer,Pearse A. Keane,Tien Yin Wong +9 more
TL;DR: There are also potential challenges with DL application in ophthalmology, including clinical and technical challenges, explainability of the algorithm results, medicolegal issues, and physician and patient acceptance of the AI ‘black-box’ algorithms.
Journal ArticleDOI
The Lancet Global Health Commission on Global Eye Health: vision beyond 2020.
Matthew J. Burton,Matthew J. Burton,Jacqueline Ramke,Jacqueline Ramke,Ana Patrícia Marques,Rupert R A Bourne,Rupert R A Bourne,Nathan Congdon,Nathan Congdon,Iain Jones,Brandon A M Ah Tong,Simon Arunga,Simon Arunga,Damodar Bachani,Covadonga Bascaran,Andrew Bastawrous,Karl Blanchet,Tasanee Braithwaite,Tasanee Braithwaite,John Buchan,John Buchan,John Cairns,Anasaini Cama,Margarida Chagunda,Chimgee Chuluunkhuu,Andrew Cooper,Jessica Crofts-Lawrence,William H. Dean,William H. Dean,Alastair K Denniston,Alastair K Denniston,Joshua R. Ehrlich,Paul M. Emerson,Jennifer R Evans,Kevin D. Frick,David S. Friedman,João M. Furtado,Gichangi M,Stephen Gichuhi,Suzanne Gilbert,Reeta Gurung,Esmael Habtamu,Peter Holland,Jost B. Jonas,Pearse A. Keane,Lisa Keay,Lisa Keay,Rohit C Khanna,Rohit C Khanna,Peng T. Khaw,Hannah Kuper,Fatima Kyari,Fatima Kyari,Van C. Lansingh,Islay Mactaggart,Milka Madaha Mafwiri,Wanjiku Mathenge,Ian McCormick,Priya Morjaria,L Mowatt,Debbie Muirhead,Debbie Muirhead,Gudlavalleti V S Murthy,Nyawira Mwangi,Nyawira Mwangi,Daksha B Patel,Tunde Peto,Babar Qureshi,Solange Rios Salomão,Virginia Sarah,Bernadetha R Shilio,Anthony W. Solomon,Bonnielin K. Swenor,Hugh R. Taylor,Ningli Wang,Aubrey Webson,Sheila K. West,Tien Yin Wong,Tien Yin Wong,Richard Wormald,Richard Wormald,Sumrana Yasmin,Mayinuer Yusufu,Juan Carlos Silva,Serge Resnikoff,Serge Resnikoff,Thulasiraj Ravilla,Clare Gilbert,Allen Foster,Hannah Faal +89 more
TL;DR: In this paper, the authors defined eye health as maximised vision, ocular health, and functional ability, thereby contributing to overall health and wellbeing, social inclusion, and quality of life.
Journal ArticleDOI
Deep learning in ophthalmology: The technical and clinical considerations.
Daniel Shu Wei Ting,Lily Peng,Avinash V. Varadarajan,Pearse A. Keane,Philippe Burlina,Michael F. Chiang,Leopold Schmetterer,Louis R. Pasquale,Neil M. Bressler,Dale R. Webster,Michael D. Abràmoff,Tien Yin Wong +11 more
TL;DR: Global eye disease burden, unmet needs and common conditions of public health importance for which AI and DL systems may be applicable are described and the potential challenges for clinical adoption are discussed.