J
Joseph San Filippo
Researcher at Yale University
Publications - 9
Citations - 2187
Joseph San Filippo is an academic researcher from Yale University. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 8, co-authored 9 publications receiving 1992 citations. Previous affiliations of Joseph San Filippo include Hoffmann-La Roche.
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Journal ArticleDOI
Mechanism of eukaryotic homologous recombination.
TL;DR: HR accessory factors that facilitate other stages of the Rad51- and Dmc1-catalyzed homologous DNA pairing and strand exchange reaction have also been identified.
Journal ArticleDOI
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry
Weixing Zhao,Sivaraja Vaithiyalingam,Joseph San Filippo,David G. Maranon,Judit Jimenez-Sainz,Gerald V. Fontenay,Youngho Kwon,Stanley G. Leung,Lucy Lu,Ryan B. Jensen,Walter J. Chazin,Claudia Wiese,Claudia Wiese,Patrick Sung +13 more
TL;DR: By targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression and may provide a paradigm for understanding the roles of D SS1 in other biological processes.
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Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.
TL;DR: It is demonstrated by biochemical means and electron microscopy that BRC3/4-DBD nucleates hRad 51 onto ssDNA and acts as a recombination mediator in enabling hRad51 to utilize replication protein A-coated ssDNA as recombination substrate.
Journal ArticleDOI
Bipartite stimulatory action of the Hop2–Mnd1 complex on the Rad51 recombinase
TL;DR: A bipartite mechanism of Hop2-Mnd1 in homologous DNA pairing is unveiled: stabilization of the Rad51 presynaptic filament and duplex DNA capture to enhance synaptic complex formation.
Journal ArticleDOI
Promotion of Homologous Recombination and Genomic Stability by RAD51AP1 via RAD51 Recombinase Enhancement
Claudia Wiese,Eloise Dray,Torsten Groesser,Joseph San Filippo,Idina Shi,David W. Collins,Miaw Sheue Tsai,Gareth J. Williams,Björn Rydberg,Patrick Sung,David Schild +10 more
TL;DR: In this article, it was shown that the RAD51 associated protein 1 (RAD51AP1) is a RAD51-interacting protein whose function has remained elusive, and that it helps maintain genomic integrity via RAD51 recombinase enhancement.