Idina Shi

TL;DR: It is shown that Hed1 does not adversely affect assembly of the Rad51 presynaptic filament, but it specifically prohibits interaction of Rad51 with Rad54, a Swi2/Snf2-like factor that is indispensable for Rad51-mediated recombination.

TL;DR: In this article, it was shown that the RAD51 associated protein 1 (RAD51AP1) is a RAD51-interacting protein whose function has remained elusive, and that it helps maintain genomic integrity via RAD51 recombinase enhancement.

TL;DR: A model where Rad52 displaces RPA from single-stranded DNA using the acidic domain as a molecular lever is proposed, and evidence to implicate an acidic domain in Rad52 in DNA repair focus formation is presented.

TL;DR: Analysis of gene conversion intermediates reveals that rad52-R70A cells can mediate DNA strand invasion but are unable to complete the recombination event, providing evidence that DNA binding by the evolutionarily conserved amino terminus of Rad52 is needed for the capture of the second DNA end during homologous recombination.

TL;DR: A mechanistic framework for rationalizing the multi-faceted role of Rad52 in recombination and DNA repair is provided and it is found that the C-terminal region of Rad 52 also harbors a DNA binding function.