M
Miaw Sheue Tsai
Researcher at Lawrence Berkeley National Laboratory
Publications - 18
Citations - 710
Miaw Sheue Tsai is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 14, co-authored 18 publications receiving 549 citations.
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Journal ArticleDOI
Promotion of Homologous Recombination and Genomic Stability by RAD51AP1 via RAD51 Recombinase Enhancement
Claudia Wiese,Eloise Dray,Torsten Groesser,Joseph San Filippo,Idina Shi,David W. Collins,Miaw Sheue Tsai,Gareth J. Williams,Björn Rydberg,Patrick Sung,David Schild +10 more
TL;DR: In this article, it was shown that the RAD51 associated protein 1 (RAD51AP1) is a RAD51-interacting protein whose function has remained elusive, and that it helps maintain genomic integrity via RAD51 recombinase enhancement.
Journal ArticleDOI
Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.
TL;DR: The results implicate the role of a proper DNA ligand in FANCD2 and FANCI monoubiquitination, and reveal regulatory mechanisms that are dependent on protein–protein and protein–DNA interactions.
Book ChapterDOI
MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes.
TL;DR: This chapter describes a multigene baculovirus system called MacroBac that uses a Biobricks-type assembly method based on restriction and ligation (Series 11) or ligation-independent cloning (Series 438) and believes that macroBac provides a critical enabling technology that may change the way that structural, biophysical, and biochemical research is done.
Journal ArticleDOI
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Arijit Dutta,Arijit Dutta,Bradley J. Eckelmann,Bradley J. Eckelmann,Sanjay Adhikari,Kazi Mokim Ahmed,Shiladitya Sengupta,Shiladitya Sengupta,Arvind Pandey,Pavana M. Hegde,Miaw Sheue Tsai,John A. Tainer,John A. Tainer,Michael Weinfeld,Muralidhar L. Hegde,Muralidhar L. Hegde,Sankar Mitra +16 more
TL;DR: The studies suggest that radiation-mediated enhancement of MMEJ in cells surviving radiation therapy may contribute to their radioresistance and could be therapeutically targeted.
Journal ArticleDOI
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
Jordi Querol-Audí,Chunli Yan,Xiao-Jun Xu,Susan E. Tsutakawa,Miaw Sheue Tsai,John A. Tainer,Priscilla K. Cooper,Eva Nogales,Eva Nogales,Eva Nogales,Ivaylo Ivanov +10 more
TL;DR: Comparing the structures of the complexes revealed key differences in the orientation and interactions of FEN1 and double-flap DNA with the two clamps that are consistent with their respective functions in providing inherent flexibility for lagging strand DNA replication or inherent stability for DNA repair.