Gareth J. Williams

TL;DR: MRN can be considered as a molecular computer that effectively assesses optimal responses and pathway choice based upon its states as set by cell status and the nature of the DNA damage and is proposed to be possible because each MRN subunit can exist in three or more distinct states.

TL;DR: This work documents a new function of PALB2: to enhance RAD51's ability to form the D loop, and demonstrates the multifaceted role of PALb2 in chromosome damage repair.

TL;DR: These new results characterize flexible ATP-dependent Mre11 regulation, defects in cancer-linked RBD mutations, conserved superfamily basic switches and motifs effecting ATP-driven conformational change, and they provide a unified comprehension of ABC–ATPase activities.

TL;DR: Crystal structures, X‐ray scattering, biochemical assays, and functional analyses of mutant PfRad50 complexes show that the ATP‐induced ‘closed’ conformation promotes DNA end binding and end tethering, while hydrolysis‐induced opening is essential for DNA resection.

TL;DR: The results point to an important role for RAD51-mediated homologous recombination in neurodevelopment, in addition to DNA repair and cancer susceptibility, as well as a dominant-negative mutation in an FA-like patient.