J
Joshua J. Conyers
Researcher at Washington University in St. Louis
Publications - 4
Citations - 3081
Joshua J. Conyers is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Myeloid leukemia & Frameshift mutation. The author has an hindex of 2, co-authored 3 publications receiving 2880 citations.
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Journal ArticleDOI
DNMT3A Mutations in Acute Myeloid Leukemia
Timothy J. Ley,Li Ding,Matthew J. Walter,Michael D. McLellan,Tamara Lamprecht,David E. Larson,Cyriac Kandoth,Jacqueline E. Payton,Jack Baty,John S. Welch,Chris Harris,Cheryl F. Lichti,R. Reid Townsend,Robert S. Fulton,David J. Dooling,Daniel C. Koboldt,Heather Schmidt,Qunyuan Zhang,John R. Osborne,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Vincent Magrini,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Joshua J. Conyers,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Joelle Kalicki,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Peter Westervelt,Michael H. Tomasson,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson +47 more
TL;DR: DNMT3A mutations are highly recurrent in patients with de novo AML with an intermediate-risk cytogenetic profile and are independently associated with a poor outcome in Cox proportional-hazards analysis.
Journal ArticleDOI
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
Timothy J. Ley,Elaine R. Mardis,Li Ding,Bob Fulton,Michael D. McLellan,Ken Chen,David J. Dooling,Brian H. Dunford-Shore,Sean McGrath,Matthew T. Hickenbotham,Lisa Cook,Rachel Abbott,David E. Larson,Daniel C. Koboldt,Craig Pohl,Scott M. Smith,Amy Hawkins,Scott Abbott,Devin P. Locke,LaDeana W. Hillier,Tracie L. Miner,Lucinda Fulton,Vincent Magrini,Todd Wylie,Jarret Glasscock,Joshua J. Conyers,Nathan Sander,Xiaoqi Shi,John R. Osborne,Patrick Minx,David Gordon,Asif T. Chinwalla,Yu Zhao,Rhonda E. Ries,Jacqueline E. Payton,Peter Westervelt,Michael H. Tomasson,Mark A. Watson,Jack Baty,Jennifer Ivanovich,Sharon Heath,William D. Shannon,Rakesh Nagarajan,Matthew J. Walter,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson +47 more
TL;DR: This study establishes whole-genome sequencing as an unbiased method for discovering cancer-initiating mutations in previously unidentified genes that may respond to targeted therapies.
Journal ArticleDOI
Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes
Timothy J. Ley,Li Ding,Matthew J. Walter,Michael D. McLellan,Tamara Lamprecht,David E. Larson,Cyriac Kandoth,Jacqueline E. Payton,Jack Baty,John S. Welch,Chris Harris,Cheryl F. Lichti,Raymond R. Townsend,Robert S. Fulton,David J. Dooling,Daniel C. Koboldt,Heather Schmidt,Qunyuan Zhang,John R. Osborne,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Vincent Magrini,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Joshua J. Conyers,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Joelle Kalicki-Veizer,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Peter Westervelt,Michael H. Tomasson,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson +47 more
TL;DR: A novel frameshift mutation in DNMT3A, one of the three genes in humans that encodes a DNA methyltransferase that catalyzes the addition of methyl groups to cytosine within CpG dinucleotides, is discovered.
Journal ArticleDOI
CO216 Understanding the Real-World Clinical Effectiveness of Pegcetacoplan for the Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH)
Jesse Fishman,Chloe Rich,K. Wilson,Jennifer Mellor,Lexus Earl,Joshua J. Conyers,Anneliese Simons +6 more
TL;DR: In this article , the clinical effectiveness of pegcetacoplan for real-world PNH patients in the USA was evaluated and compared with traditional C3/C5 inhibitors (e.g., C5 inhibitors) to manage complement driven hemolysis and associated symptoms.