J
John R. Osborne
Researcher at Washington University in St. Louis
Publications - 9
Citations - 13715
John R. Osborne is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Gene & Mutation. The author has an hindex of 7, co-authored 9 publications receiving 12670 citations.
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Journal ArticleDOI
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Roger E. McLendon,Allan H. Friedman,Darrell D. Bigner,Erwin G. Van Meir,Daniel J. Brat,Gena M. Mastrogianakis,Jeffrey J. Olson,Tom Mikkelsen,Norman L. Lehman,Kenneth Aldape,W. K. Alfred Yung,Oliver Bogler,John N. Weinstein,Scott R. VandenBerg,Mitchel S. Berger,Michael D. Prados,Donna M. Muzny,Margaret Morgan,Steve Scherer,Aniko Sabo,Lynn Nazareth,Lora Lewis,Otis Hall,Yiming Zhu,Yanru Ren,Omar Alvi,Jiqiang Yao,Alicia Hawes,Shalini N. Jhangiani,Gerald R. Fowler,Anthony San Lucas,Christie Kovar,Andrew Cree,Huyen Dinh,Jireh Santibanez,Vandita Joshi,Manuel L. Gonzalez-Garay,Christopher A. Miller,Aleksandar Milosavljevic,Lawrence A. Donehower,David A. Wheeler,Richard A. Gibbs,Kristian Cibulskis,Carrie Sougnez,Timothy Fennell,Scott Mahan,Jane Wilkinson,Liuda Ziaugra,Robert C. Onofrio,Toby Bloom,Rob Nicol,Kristin G. Ardlie,Jennifer Baldwin,Stacey Gabriel,Eric S. Lander,Eric S. Lander,Li Ding,Robert S. Fulton,Michael D. McLellan,John W. Wallis,David E. Larson,Xiaoqi Shi,Rachel Abbott,Lucinda Fulton,Ken Chen,Daniel C. Koboldt,Michael C. Wendl,Rick Meyer,Yuzhu Tang,Ling Lin,John R. Osborne,Brian H. Dunford-Shore,Tracie L. Miner,Kim D. Delehaunty,Chris Markovic,Gary W. Swift,William Courtney,Craig Pohl,Scott Abbott,Amy Hawkins,Shin Leong,Carrie A. Haipek,Heather Schmidt,Maddy Wiechert,Tammi L. Vickery,Sacha Scott,David J. Dooling,Asif T. Chinwalla,George M. Weinstock,Elaine R. Mardis,Richard K. Wilson,Gad Getz,Wendy Winckler,Roel G.W. Verhaak,Michael S. Lawrence,Michael J. T. O’Kelly,James A. Robinson,Gabriele Alexe,Rameen Beroukhim,Scott L. Carter,Derek Y. Chiang,Josh Gould,Supriya Gupta,Josh Korn,Craig H. Mermel,Jill P. Mesirov,Stefano Monti,Huy V. Nguyen,Melissa Parkin,Michael R. Reich,Nicolas Stransky,Barbara A. Weir,Levi A. Garraway,Todd R. Golub,Matthew Meyerson,Lynda Chin,Alexei Protopopov,Jianhua Zhang,Ilana Perna,Sandy Aronson,Narayanan Sathiamoorthy,Georgia Ren,Jun Yao,W. Ruprecht Wiedemeyer,Hyun Soo Kim,Won Kong Sek,Yonghong Xiao,Isaac S. Kohane,Jon G. Seidman,Peter J. Park,Raju Kucherlapati,Peter W. Laird,Leslie Cope,James G. Herman,Daniel J. Weisenberger,Fei Pan,David Van Den Berg,Leander Van Neste,Mi Yi Joo,Kornel E. Schuebel,Stephen B. Baylin,Devin Absher,Jun Li,Audrey Southwick,Shannon T. Brady,Amita Aggarwal,Tisha Chung,Gavin Sherlock,James D. Brooks,Richard M. Myers,Paul T. Spellman,Elizabeth Purdom,Lakshmi Jakkula,Anna Lapuk,Henry Marr,Shannon Dorton,Gi Choi Yoon,Ju Han,Amrita Ray,Victoria Wang,Steffen Durinck,Mark D. Robinson,Nicholas J. Wang,Karen Vranizan,Vivian Peng,Eric Van Name,Gerald V. Fontenay,John Ngai,John G. Conboy,Bahram Parvin,Heidi S. Feiler,Terence P. Speed,Terence P. Speed,Joe W. Gray,Cameron Brennan,Nicholas D. Socci,Adam B. Olshen,Barry S. Taylor,Barry S. Taylor,Alex E. Lash,Nikolaus Schultz,Boris Reva,Yevgeniy Antipin,Alexey Stukalov,Benjamin Gross,Ethan Cerami,Qing Wang Wei,Li-Xuan Qin,Venkatraman E. Seshan,Liliana Villafania,Magali Cavatore,Laetitia Borsu,Agnes Viale,William L. Gerald,Chris Sander,Marc Ladanyi,Charles M. Perou,D. Neil Hayes,Michael D. Topal,Katherine A. Hoadley,Yuan Qi,Sai Balu,Yan Shi,Junyuan Wu,Robert Penny,Michael L. Bittner,Troy Shelton,Elizabeth Lenkiewicz,Scott Morris,Debbie Beasley,Sheri Sanders,Ari B. Kahn,Robert Sfeir,Jessica Chen,David Nassau,Larry Feng,Erin Hickey,Anna D. Barker,Daniela S. Gerhard,Joseph G. Vockley,Carolyn C. Compton,Jim Vaught,Peter Fielding,Martin L. Ferguson,Carl F. Schaefer,Jinghui Zhang,Subhashree Madhavan,Kenneth H. Buetow,Francis S. Collins,Peter J. Good,Mark S. Guyer,Brad Ozenberger,Jane Peterson,Elizabeth J. Thomson +233 more
TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
Journal ArticleDOI
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding,Gad Getz,David A. Wheeler,Elaine R. Mardis,Michael D. McLellan,Kristian Cibulskis,Carrie Sougnez,Heidi Greulich,Heidi Greulich,Donna M. Muzny,Margaret Morgan,Lucinda Fulton,Robert S. Fulton,Qunyuan Zhang,Michael C. Wendl,Michael S. Lawrence,David E. Larson,Ken Chen,David J. Dooling,Aniko Sabo,Alicia Hawes,Hua Shen,Shalini N. Jhangiani,Lora Lewis,Otis Hall,Yiming Zhu,Tittu Mathew,Yanru Ren,Jiqiang Yao,Steven E. Scherer,Kerstin Clerc,Ginger A. Metcalf,Brian Ng,Aleksandar Milosavljevic,Manuel L. Gonzalez-Garay,John R. Osborne,Rick Meyer,Xiaoqi Shi,Yuzhu Tang,Daniel C. Koboldt,Ling Lin,Rachel Abbott,Tracie L. Miner,Craig Pohl,Ginger A. Fewell,Carrie A. Haipek,Heather Schmidt,Brian H. Dunford-Shore,Aldi T. Kraja,Seth D. Crosby,Christopher S. Sawyer,Tammi L. Vickery,Sacha N. Sander,Jody S. Robinson,Wendy Winckler,Wendy Winckler,Jennifer Baldwin,Lucian R. Chirieac,Amit Dutt,Amit Dutt,Timothy Fennell,Megan Hanna,Megan Hanna,Bruce E. Johnson,Robert C. Onofrio,Roman K. Thomas,Giovanni Tonon,Barbara A. Weir,Barbara A. Weir,Xiaojun Zhao,Xiaojun Zhao,Liuda Ziaugra,Michael C. Zody,Thomas J. Giordano,Mark B. Orringer,Jack A. Roth,Margaret R. Spitz,Ignacio I. Wistuba,Bradley A. Ozenberger,Peter J. Good,Andrew C. Chang,David G. Beer,Mark A. Watson,Marc Ladanyi,Stephen R. Broderick,Akihiko Yoshizawa,William D. Travis,William Pao,Michael A. Province,George M. Weinstock,Harold E. Varmus,Stacey Gabriel,Eric S. Lander,Richard A. Gibbs,Matthew Meyerson,Matthew Meyerson,Richard K. Wilson +96 more
TL;DR: Somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B are found.
Journal ArticleDOI
DNMT3A Mutations in Acute Myeloid Leukemia
Timothy J. Ley,Li Ding,Matthew J. Walter,Michael D. McLellan,Tamara Lamprecht,David E. Larson,Cyriac Kandoth,Jacqueline E. Payton,Jack Baty,John S. Welch,Chris Harris,Cheryl F. Lichti,R. Reid Townsend,Robert S. Fulton,David J. Dooling,Daniel C. Koboldt,Heather Schmidt,Qunyuan Zhang,John R. Osborne,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Sean McGrath,Lucinda Fulton,Vincent Magrini,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Joshua J. Conyers,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Joelle Kalicki,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Peter Westervelt,Michael H. Tomasson,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Elaine R. Mardis,Richard K. Wilson +47 more
TL;DR: DNMT3A mutations are highly recurrent in patients with de novo AML with an intermediate-risk cytogenetic profile and are independently associated with a poor outcome in Cox proportional-hazards analysis.
Journal ArticleDOI
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
Timothy J. Ley,Elaine R. Mardis,Li Ding,Bob Fulton,Michael D. McLellan,Ken Chen,David J. Dooling,Brian H. Dunford-Shore,Sean McGrath,Matthew T. Hickenbotham,Lisa Cook,Rachel Abbott,David E. Larson,Daniel C. Koboldt,Craig Pohl,Scott M. Smith,Amy Hawkins,Scott Abbott,Devin P. Locke,LaDeana W. Hillier,Tracie L. Miner,Lucinda Fulton,Vincent Magrini,Todd Wylie,Jarret Glasscock,Joshua J. Conyers,Nathan Sander,Xiaoqi Shi,John R. Osborne,Patrick Minx,David Gordon,Asif T. Chinwalla,Yu Zhao,Rhonda E. Ries,Jacqueline E. Payton,Peter Westervelt,Michael H. Tomasson,Mark A. Watson,Jack Baty,Jennifer Ivanovich,Sharon Heath,William D. Shannon,Rakesh Nagarajan,Matthew J. Walter,Daniel C. Link,Timothy A. Graubert,John F. DiPersio,Richard K. Wilson +47 more
TL;DR: This study establishes whole-genome sequencing as an unbiased method for discovering cancer-initiating mutations in previously unidentified genes that may respond to targeted therapies.
Journal ArticleDOI
Characterizing the cancer genome in lung adenocarcinoma
Barbara A. Weir,Barbara A. Weir,Michele S. Woo,Gad Getz,Sven Perner,Sven Perner,Li Ding,Rameen Beroukhim,Rameen Beroukhim,William M. Lin,William M. Lin,Michael A. Province,Aldi T. Kraja,Laura A. Johnson,Kinjal Shah,Kinjal Shah,Mitsuo Sato,Roman K. Thomas,Justine A. Barletta,Ingrid B. Borecki,Stephen R. Broderick,Andrew C. Chang,Derek Y. Chiang,Derek Y. Chiang,Lucian R. Chirieac,Jeonghee Cho,Yoshitaka Fujii,Adi F. Gazdar,Thomas J. Giordano,Heidi Greulich,Heidi Greulich,Megan Hanna,Megan Hanna,Bruce E. Johnson,Mark G. Kris,Alex E. Lash,Ling Lin,Neal I. Lindeman,Elaine R. Mardis,John Douglas Mcpherson,John D. Minna,Margaret Morgan,Mark Nadel,Mark Nadel,Mark B. Orringer,John R. Osborne,Brad Ozenberger,Alex H. Ramos,Alex H. Ramos,James T. Robinson,Jack A. Roth,Valerie W. Rusch,Hidefumi Sasaki,Frances A. Shepherd,Carrie Sougnez,Margaret R. Spitz,Ming-Sound Tsao,David Twomey,Roel G.W. Verhaak,George M. Weinstock,David A. Wheeler,Wendy Winckler,Wendy Winckler,Akihiko Yoshizawa,Soyoung Yu,Maureen F. Zakowski,Qunyuan Zhang,David G. Beer,Ignacio I. Wistuba,Mark A. Watson,Levi A. Garraway,Levi A. Garraway,Marc Ladanyi,William D. Travis,William Pao,Mark A. Rubin,Mark A. Rubin,Stacey Gabriel,Richard A. Gibbs,Harold E. Varmus,Richard K. Wilson,Eric S. Lander,Eric S. Lander,Eric S. Lander,Matthew Meyerson,Matthew Meyerson +85 more
TL;DR: A large-scale project to characterize copy-number alterations in primary lung adenocarcinomas using dense single nucleotide polymorphism arrays identifies NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung carcinomas.