抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Although gold is the subject of one of the most ancient themes of investigation in science, its renaissance now leads to an exponentially increasing number of publications, especially in the context of emerging nanoscience and nanotechnology with nanoparticles and self-assembled monolayers (SAMs). We will limit the present review to gold nanoparticles (AuNPs), also called gold colloids. AuNPs are the most stable metal nanoparticles, and they present fascinating aspects such as their assembly of multiple types involving materials science, the behavior of the individual particles, size-related electronic, magnetic and optical properties (quantum size effect), and their applications to catalysis and biology. Their promises are in these fields as well as in the bottom-up approach of nanotechnology, and they will be key materials and building block in the 21st century. Whereas the extraction of gold started in the 5th millennium B.C. near Varna (Bulgaria) and reached 10 tons per year in Egypt around 1200-1300 B.C. when the marvelous statue of Touthankamon was constructed, it is probable that “soluble” gold appeared around the 5th or 4th century B.C. in Egypt and China. In antiquity, materials were used in an ecological sense for both aesthetic and curative purposes. Colloidal gold was used to make ruby glass 293 Chem. Rev. 2004, 104, 293−346

Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.

The optical properties of metal nanoparticles have long been of interest in physical chemistry, starting with Faraday's investigations of colloidal gold in the middle 1800s. More recently, new lithographic techniques as well as improvements to classical wet chemistry methods have made it possible to synthesize noble metal nanoparticles with a wide range of sizes, shapes, and dielectric environments. In this feature article, we describe recent progress in the theory of nanoparticle optical properties, particularly methods for solving Maxwell's equations for light scattering from particles of arbitrary shape in a complex environment. Included is a description of the qualitative features of dipole and quadrupole plasmon resonances for spherical particles; a discussion of analytical and numerical methods for calculating extinction and scattering cross-sections, local fields, and other optical properties for nonspherical particles; and a survey of applications to problems of recent interest involving triangula...

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The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment

Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. ZnO is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination, ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), OH− (hydroxyl radicals), and O2 −2 (peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to ZnO-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions. These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on ZnO abrasive surface texture. One functional application of the ZnO antibacterial bioactivity was discussed in food packaging industry where ZnO-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of ZnO-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition.

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Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism.

The development of novel materials is a fundamental focal point of chemical research; and this interest is mandated by advancements in all areas of industry and technology. A good example of the synergism between scientific discovery and technological development is the electronics industry, where discoveries of new semiconducting materials resulted in the evolution from vacuum tubes to diodes and transistors, and eventually to miniature chips. The progression of this technology led to the development * To whom correspondence should be addressed. B.L.C.: (504) 2801385 (phone); (504) 280-3185 (fax); bcushing@uno.edu (e-mail). C.J.O.: (504)280-6846(phone);(504)280-3185(fax);coconnor@uno.edu (e-mail). 3893 Chem. Rev. 2004, 104, 3893−3946

http://depa.fquim.unam.mx/amyd//archivero/FidelmarLechugaSanabria_4940.pdf

Recent advances in the liquid-phase syntheses of inorganic nanoparticles.

An Extended Randles Circuit and a Systematic Model-Development Approach for Capacitive Deionization

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Growth, microstructure and sintering behavior of nanosized silicon powders

Lack of potable water in communities across the globe is a serious humanitarian problem promoting the desalination of saline water (seawater and brackish water) to meet the growing demands of human civilization Multiple ionic species can be present in natural water sources in addition to sodium chloride, and capacitive deionization (CDI) is an upcoming technology with the potential to address these challenges because of its efficacy in removing charged species from water by electro-adsorption In this work, we have investigated the effect of device operation on the preferential removal of different ionic species A dynamic Langmuir (DL) model has been a starting point for deriving the theory, and the model predictions have been validated using data from reports in the literature Crucially, we derive a simple relationship between the adsorption of different ionic species for short and long adsorption periods This is leveraged to directly predict and enhance the selective ion removal in CDI Furthermore, we demonstrate an example of how this selectivity could reduce excess removal of ions to avoid remineralization needs In conclusion, the method could be valuable for predicting the impact of improved device operation on capacitive deionization with multi-ion compositions prevalent in natural water sources

Predicting and Enhancing the Ion Selectivity in Multi-Ion Capacitive Deionization

Environmental pollution and industrialization on a global scale have drawn attention to the vital need for developing new hygienically friendly purification technologies. The most common indoor and outdoor purification techniques like ozonation, chlorination, filtration etc... has their corresponding limitations of electricity and/or other energy sources. However strong contender as environmentally harmonious decontamination process and an exclusive source of producing the most powerful oxidative agent (hydroxyl radical) is heterogeneous photocatalysis which make use of photocatalysts that operate at room temperature and in a clean manner. Applications of such safe, lower energy consumer, efficient generator of hydroxyl radical and bactericidal competent photocatalytic systems are urgently desired for the purification of naturally and/or humanly polluted water, the decomposition of offensive atmospheric odors and decomposition of NOx compounds on a huge scale. To address such enormous tasks, heterogeneous photocatalytic systems via metal oxide semiconductors like ZnO, that are capable to operate effectively and efficiently under UV light must be established. We have developed metal oxide semiconductors with tailored optical absorption characteristics, namely ZnO nanoparticles that are capable of decontaminating water from organic compounds. Results of experiments with ZnO nanoparticles for photocatalytic decomposition of organic compound have been described in this work

Joydeep Dutta

Papers

An Extended Randles Circuit and a Systematic Model-Development Approach for Capacitive Deionization

Growth, microstructure and sintering behavior of nanosized silicon powders

Predicting and Enhancing the Ion Selectivity in Multi-Ion Capacitive Deionization

Photocatalytic activities of ZnO nanoparticles synthesized by wet chemical techniques

Zinc Oxide Nanowires on Non-Epitaxial Substrates from Colloidal Processing, for Gas Sensing Applications