E
Edward A. Sykes
Researcher at Queen's University
Publications - 26
Citations - 2943
Edward A. Sykes is an academic researcher from Queen's University. The author has contributed to research in topics: Knot (unit) & Cellular differentiation. The author has an hindex of 15, co-authored 26 publications receiving 2274 citations. Previous affiliations of Edward A. Sykes include University of Toronto.
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Journal ArticleDOI
Mechanism of hard-nanomaterial clearance by the liver
Kim Tsoi,Sonya A. MacParland,Xue Zhong Ma,Vinzent N. Spetzler,Juan Echeverri,Ben Ouyang,Saleh M. Fadel,Edward A. Sykes,Nicolas Goldaracena,Johann Moritz Kaths,John B. Conneely,Benjamin A. Alman,Markus Selzner,Mario A. Ostrowski,Oyedele Adeyi,Anton Zilman,Ian D. McGilvray,Warren C. W. Chan +17 more
TL;DR: It is found that nanomaterial velocity reduces 1000-fold as they enter and traverse the liver, leading to 7.5 times morenanomaterial interaction with hepatic cells relative to peripheral cells.
Journal ArticleDOI
Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency.
TL;DR: It is demonstrated that tumor accumulation can be mediated by high nanoparticle avidity and are weakly dependent on their plasma clearance rate, and empirical models can be used to rapidly screen novel nanomaterials for relative differences in tumor targeting without the need for animal work.
Journal ArticleDOI
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine
Kimberly J. Dunham-Snary,Danchen Wu,Edward A. Sykes,Amar Thakrar,Leah R. G. Parlow,Jeffrey Mewburn,Joel L. Parlow,Stephen L. Archer +7 more
TL;DR: HPV commonly occurs as a localized homeostatic response to focal pneumonia or atelectasis, which optimizes systemic Po2 without altering pulmonary artery pressure (PAP).
Journal ArticleDOI
Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
Alexandre Albanese,Alan K. Lam,Alan K. Lam,Edward A. Sykes,Jonathan V. Rocheleau,Jonathan V. Rocheleau,Warren C. W. Chan +6 more
TL;DR: It is shown that penetration of nanoparticles into the tissue is limited by their diameter and retention can be improved by receptor-targeting, and that the tumour-on-a-chip can be useful for screening optimal nanoparticle designs prior to in vivo studies.
Journal ArticleDOI
Tailoring nanoparticle designs to target cancer based on tumor pathophysiology
Edward A. Sykes,Qin Dai,Christopher D. Sarsons,Juan Chen,Jonathan V. Rocheleau,David M. Hwang,Gang Zheng,David T. Cramb,Kristina D. Rinker,Warren C. W. Chan +9 more
TL;DR: It is discovered that changes in pathophysiology associated with tumor volume can selectively change tumor uptake of nanoparticles of varying size, and this finding presents a paradigm shift in nanomedicine away from identifying and using a universal nanoparticle design for cancer detection and treatment.