J
Juan I. Moliva
Researcher at National Institutes of Health
Publications - 24
Citations - 2786
Juan I. Moliva is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 6, co-authored 16 publications receiving 1107 citations.
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Journal ArticleDOI
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
Matthew Gagne,Juan I. Moliva,Kathryn E. Foulds,Shayne Andrew,Barbara J. Flynn,Anne P. Werner,Danielle A Wagner,I-Ting Teng,Bob C. Lin,Christopher Brooks Moore,Nazaire Jean-Baptiste,Robin E. Carroll,Stephanie L. Foster,Mit Patel,Madison Ellis,Venkata Viswanadh Edara,Nahara Vargas Maldonado,Mahnaz Minai,Lauren McCormick,Christopher Cole Honeycutt,Bianca M. Nagata,Kevin W. Bock,Caitlyn N. M. Dulan,Jamilet Cordon,Dillon R. Flebbe,John Paul Todd,Elizabeth McCarthy,Laurent Pessaint,Alex Van Ry,Brandon Narvaez,Daniel Valentin,Anthony Cook,Alan Dodson,Katelyn Steingrebe,Saule Nurmukhambetova,Sucheta Godbole,Amy R. Henry,Farida Laboune,Jesmine Roberts-Torres,Cynthia G. Lorang,Shivani G. Amin,Jessica F. Trost,M. Naisan,Manjula Basappa,J. B. Willis,Lingshu Wang,Wei Shi,Nicole A. Doria-Rose,Yi Zhang,Eun Sung Yang,Kwanyee Leung,Sijy O'Dell,R. Schmidt,Adam S. Olia,Cuiping Liu,Darcy R. Harris,Gwo-Yu Chuang,Guillaume Stewart-Jones,Isabella Renzi,Yen-Ting Lai,Agata Malinowski,Kai Wu,John R. Mascola,Andrea Carfi,Peter D. Kwong,Darin K. Edwards,Mark A. Lewis,Hanne Andersen,Kizzmekia S. Corbett,Martha Nason,Adrian B. McDermott,Mehul S. Suthar,Ian N. Moore,Mario Roederer,Nancy J. Sullivan,Daniel C. Douek,Robert A. Seder +76 more
TL;DR: In this article , the authors showed that boosting with Omicron-matched vaccines would enhance protection, but it is unclear whether boosting with omicron matched vaccines would improve protection.
Journal ArticleDOI
A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone.
Baoshan Zhang,Cara W. Chao,Yaroslav Tsybovsky,Olubukola M. Abiona,Geoffrey B. Hutchinson,Juan I. Moliva,Adam S. Olia,Amarendra Pegu,Emily Phung,Emily Phung,Guillaume Stewart-Jones,Raffaello Verardi,Lingshu Wang,Shuishu Wang,Anne P. Werner,Eun Sung Yang,Christina Yap,Tongqing Zhou,John R. Mascola,Nancy J. Sullivan,Barney S. Graham,Kizzmekia S. Corbett,Peter D. Kwong +22 more
TL;DR: A plug-and-play platform using the spontaneous isopeptide-bond formation of the SpyTag:SpyCatcher system to display trimeric antigens on self-assembling nanoparticles, with SARS-CoV-2 spike-LuS nanoparticles inducing particularly potent neutralizing responses.
Posted ContentDOI
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron
Matthew Gagne,Juan I. Moliva,Kathryn E. Foulds,Shayne Andrew,Barbara J. Flynn,Anne P. Werner,Danielle A Wagner,I-Ting Teng,Bob C. Lin,Christopher Brooks Moore,Nazaire Jean-Baptiste,Robert B. Carroll,Stephanie L. Foster,Mit Patel,Madison Ellis,Venkata Viswanadh Edara,Nahara Vargas Maldonado,Mahnaz Minai,Lauren McCormick,Christopher Cole Honeycutt,Bianca M. Nagata,Kevin W. Bock,Caitlyn N. M. Dulan,Jamilet Cordon,John Paul Todd,Elizabeth McCarthy,Laurent Pessaint,Alex Van Ry,Brandon Narvaez,Daniel Valentin,Anthony Cook,Alan Dodson,Katelyn Steingrebe,Dillon R. Flebbe,Saule Nurmukhambetova,Sucheta Godbole,Amy R. Henry,Farida Laboune,Jesmine Roberts-Torres,Cynthia G. Lorang,Shivani G. Amin,Jessica F. Trost,M. Naisan,Manjula Basappa,J. B. Willis,Lingshu Wang,Wei Shi,Nicole A. Doria-Rose,Adam S. Olia,Cuiping Liu,Darcy R. Harris,Andrea Carfi,John R. Mascola,Peter D. Kwong,Darin K. Edwards,Hanne Andersen,Mark A. Lewis,Kizzmekia S. Corbett,Martha Nason,Adrian B. McDermott,Mehul S. Suthar,Ian N. Moore,Mario Roederer,Nancy J. Sullivan,Daniel C. Douek,Robert A. Seder +65 more
TL;DR: An SARS-CoV-2 Omicron boost may not provide greater immunity or protection compared to a boost with the current mRNA-1273 vaccine.
Journal ArticleDOI
Protection against SARS-CoV-2 beta variant in mRNA-1273 vaccine-boosted nonhuman primates.
Kizzmekia S. Corbett,Matthew Gagne,Danielle A. Wagner,Sarah O’ Connell,Sandeep Narpala,Dillon R. Flebbe,Shayne F. Andrew,Rachel L. Davis,Barbara J. Flynn,Timothy S. Johnston,Christopher D. Stringham,Lilin Lai,Daniel Valentin,Alex Van Ry,Zackery Flinchbaugh,Anne P. Werner,Juan I. Moliva,Manjari Sriparna,Sijy O'Dell,Stephen D. Schmidt,Courtney Tucker,Angela Choi,Matthew A. Koch,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Gabriela S. Alvarado,Amy R. Henry,Farida Laboune,Chaim A. Schramm,Yi Zhang,Eun Sung Yang,Lingshu Wang,Misook Choe,Seyhan Boyoglu-Barnum,Shi Wei,Evan Lamb,Saule T. Nurmukhambetova,Samantha J. Provost,Mitzi M. Donaldson,Josue Marquez,John-Paul Todd,Anthony L. Cook,Alan Dodson,Andrew Pekosz,Eli Boritz,Aurélie Ploquin,Nicole A. Doria-Rose,Laurent Pessaint,Hanne Leth Andersen,Kathryn E. Foulds,John Misasi,Kai Wu,Andrea Carfi,Martha Nason,John R. Mascola,Ian N. Moore,Darin K. Edwards,Mark G. Lewis,Mehul S. Suthar,Mario Roederer,Adrian B. McDermott,Daniel C. Douek,Nancy J. Sullivan,Barney S. Graham,Robert A. Seder +65 more
TL;DR: In this paper, the authors evaluated the immune responses in nonhuman prima... and found that neutralizing antibody responses gradually wane against several variants of concern after vaccination with the SARS-CoV-2 vaccine mRNA-1273.
Posted ContentDOI
Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates
Kizzmekia S. Corbett,Martha Nason,Britta Flach,Matthew Gagne,Timothy S. Johnston,Shruti N. Shah,Venkata Vishwanadh Edara,Katharine Floyd,Lilin Lai,Charlene McDanal,Joseph R. Francica,Barbara J. Flynn,Kai Wu,Angela Choi,Matthew A. Koch,Olubukola M. Abiona,Anne P. Werner,Gabriela S. Alvarado,Shayne F. Andrew,Mitzi M. Donaldson,Jonathan Fintzi,Dillon R. Flebbe,Evan Lamb,Amy T. Noe,Saule T. Nurmukhambetova,Samantha J. Provost,Anthony L. Cook,Alan Dodson,Andrew Faudree,Jack Greenhouse,Swagata Kar,Laurent Pessaint,Maciel Porto,Katelyn Steingrebe,Daniel Valentin,Serge Zouantcha,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Juan I. Moliva,Renee van de Wetering,Seyhan Boyoglu-Barnum,Kwanyee Leung,Wei Shi,Eun Sung Yang,Yi Zhang,John-Paul Todd,Lingshu Wang,Hanne Leth Andersen,Kathryn E. Foulds,Darin K. Edwards,John R. Mascola,Ian N. Moore,Mark G. Lewis,Andrea Carfi,David C. Montefiori,Mehul S. Suthar,Adrian B. McDermott,Nancy J. Sullivan,Mario Roederer,Daniel C. Douek,Barney S. Graham,Robert A. Seder +62 more
TL;DR: In this article, a nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of human infection and may be used to define immune correlates of protection following vaccination.