T
Timothy S. Johnston
Researcher at National Institutes of Health
Publications - 8
Citations - 424
Timothy S. Johnston is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antibody & Vaccination. The author has an hindex of 6, co-authored 8 publications receiving 95 citations.
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Journal ArticleDOI
Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates.
Kizzmekia S. Corbett,Martha Nason,Britta Flach,Matthew Gagne,Sarah O’Connell,Timothy S. Johnston,Shruti N. Shah,Venkata Viswanadh Edara,Katharine Floyd,Lilin Lai,Charlene McDanal,Joseph R. Francica,Barbara J. Flynn,Kai Wu,Angela Choi,Matthew A. Koch,Olubukola M. Abiona,Anne P. Werner,Juan I. Moliva,Shayne F. Andrew,Mitzi M. Donaldson,Jonathan Fintzi,Dillon R. Flebbe,Evan Lamb,Amy T. Noe,Saule T. Nurmukhambetova,Samantha J. Provost,Anthony L. Cook,Alan Dodson,Andrew Faudree,Jack Greenhouse,Swagata Kar,Laurent Pessaint,Maciel Porto,Katelyn Steingrebe,Daniel Valentin,Serge Zouantcha,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Renee van de Wetering,Seyhan Boyoglu-Barnum,Kwanyee Leung,Wei Shi,Eun Sung Yang,Yi Zhang,John Paul Todd,Lingshu Wang,Gabriela S. Alvarado,Hanne Leth Andersen,Kathryn E. Foulds,Darin K. Edwards,John R. Mascola,Ian N. Moore,Mark G. Lewis,Andrea Carfi,David C. Montefiori,Mehul S. Suthar,Adrian B. McDermott,Mario Roederer,Nancy J. Sullivan,Daniel C. Douek,Barney S. Graham,Robert A. Seder +63 more
TL;DR: In this paper, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 μg of the mRNA-12 protein, which can be used as surrogate endpoints for vaccine efficacy.
Journal ArticleDOI
Protection against SARS-CoV-2 beta variant in mRNA-1273 vaccine-boosted nonhuman primates.
Kizzmekia S. Corbett,Matthew Gagne,Danielle A. Wagner,Sarah O’ Connell,Sandeep Narpala,Dillon R. Flebbe,Shayne F. Andrew,Rachel L. Davis,Barbara J. Flynn,Timothy S. Johnston,Christopher D. Stringham,Lilin Lai,Daniel Valentin,Alex Van Ry,Zackery Flinchbaugh,Anne P. Werner,Juan I. Moliva,Manjari Sriparna,Sijy O'Dell,Stephen D. Schmidt,Courtney Tucker,Angela Choi,Matthew A. Koch,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Gabriela S. Alvarado,Amy R. Henry,Farida Laboune,Chaim A. Schramm,Yi Zhang,Eun Sung Yang,Lingshu Wang,Misook Choe,Seyhan Boyoglu-Barnum,Shi Wei,Evan Lamb,Saule T. Nurmukhambetova,Samantha J. Provost,Mitzi M. Donaldson,Josue Marquez,John-Paul Todd,Anthony L. Cook,Alan Dodson,Andrew Pekosz,Eli Boritz,Aurélie Ploquin,Nicole A. Doria-Rose,Laurent Pessaint,Hanne Leth Andersen,Kathryn E. Foulds,John Misasi,Kai Wu,Andrea Carfi,Martha Nason,John R. Mascola,Ian N. Moore,Darin K. Edwards,Mark G. Lewis,Mehul S. Suthar,Mario Roederer,Adrian B. McDermott,Daniel C. Douek,Nancy J. Sullivan,Barney S. Graham,Robert A. Seder +65 more
TL;DR: In this paper, the authors evaluated the immune responses in nonhuman prima... and found that neutralizing antibody responses gradually wane against several variants of concern after vaccination with the SARS-CoV-2 vaccine mRNA-1273.
Journal ArticleDOI
Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates.
Joseph R. Francica,Barbara J. Flynn,Kathryn E. Foulds,Amy T. Noe,Anne P. Werner,Ian N. Moore,Matthew Gagne,Timothy S. Johnston,Courtney Tucker,Rachel L. Davis,Britta Flach,Sarah O’Connell,Shayne F. Andrew,Evan Lamb,Dillon R. Flebbe,Saule T. Nurmukhambetova,Mitzi M. Donaldson,John-Paul Todd,Alex Lee Zhu,Alex Lee Zhu,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,Matthew J. Gorman,Sally Shin,Venkata Viswanadh Edara,Venkata Viswanadh Edara,Katharine Floyd,Katharine Floyd,Lilin Lai,Lilin Lai,Seyhan Boyoglu-Barnum,Renee van de Wetering,Alida Tylor,Elizabeth McCarthy,Valerie Lecouturier,Sophie Ruiz,Catherine C. Berry,Timothy Tibbitts,Hanne Leth Andersen,Anthony L. Cook,Alan Dodson,Laurent Pessaint,Alex Van Ry,Marguerite Koutsoukos,Cindy Gutzeit,I.-Ting Teng,Tongqing Zhou,Dapeng Li,Barton F. Haynes,Peter D. Kwong,Adrian B. McDermott,Mark G. Lewis,Tong-Ming Fu,Roman Chicz,Robbert van der Most,Kizzmekia S. Corbett,Mehul S. Suthar,Mehul S. Suthar,Galit Alter,Mario Roederer,Nancy J. Sullivan,Daniel C. Douek,Barney S. Graham,Danilo Casimiro,Robert A. Seder +66 more
TL;DR: In this article, soluble prefusion-stabilized spike protein trimers from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were formulated with the adjuvant AS03 and administered twice to nonhuman primates (NHPs).
Posted ContentDOI
Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates
Kizzmekia S. Corbett,Martha Nason,Britta Flach,Matthew Gagne,Timothy S. Johnston,Shruti N. Shah,Venkata Vishwanadh Edara,Katharine Floyd,Lilin Lai,Charlene McDanal,Joseph R. Francica,Barbara J. Flynn,Kai Wu,Angela Choi,Matthew A. Koch,Olubukola M. Abiona,Anne P. Werner,Gabriela S. Alvarado,Shayne F. Andrew,Mitzi M. Donaldson,Jonathan Fintzi,Dillon R. Flebbe,Evan Lamb,Amy T. Noe,Saule T. Nurmukhambetova,Samantha J. Provost,Anthony L. Cook,Alan Dodson,Andrew Faudree,Jack Greenhouse,Swagata Kar,Laurent Pessaint,Maciel Porto,Katelyn Steingrebe,Daniel Valentin,Serge Zouantcha,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Juan I. Moliva,Renee van de Wetering,Seyhan Boyoglu-Barnum,Kwanyee Leung,Wei Shi,Eun Sung Yang,Yi Zhang,John-Paul Todd,Lingshu Wang,Hanne Leth Andersen,Kathryn E. Foulds,Darin K. Edwards,John R. Mascola,Ian N. Moore,Mark G. Lewis,Andrea Carfi,David C. Montefiori,Mehul S. Suthar,Adrian B. McDermott,Nancy J. Sullivan,Mario Roederer,Daniel C. Douek,Barney S. Graham,Robert A. Seder +62 more
TL;DR: In this article, a nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of human infection and may be used to define immune correlates of protection following vaccination.
Journal ArticleDOI
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.
Kizzmekia S. Corbett,Kizzmekia S. Corbett,Anne P. Werner,Sarah O’ Connell,Matthew Gagne,Lilin Lai,Juan I. Moliva,Barbara J. Flynn,Angela Choi,Matthew A. Koch,Kathryn E. Foulds,Shayne F. Andrew,Dillon R. Flebbe,Evan Lamb,Saule T. Nurmukhambetova,Samantha J. Provost,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Alex Van Ry,Zackery Flinchbaugh,Timothy S. Johnston,Elham Bayat Mokhtari,Prakriti Mudvari,Amy R. Henry,Farida Laboune,Becky Chang,Maciel Porto,Jaclyn Wear,Gabriela S. Alvarado,Seyhan Boyoglu-Barnum,John-Paul Todd,Bridget Bart,Anthony Cook,Alan Dodson,Laurent Pessaint,Katelyn Steingrebe,Sayda Elbashir,Manjari Sriparna,Andrew Pekosz,Hanne Leth Andersen,Kai Wu,Darin K. Edwards,Swagata Kar,Mark G. Lewis,Eli Boritz,Ian N. Moore,Andrea Carfi,Mehul S. Suthar,Adrian B. McDermott,Mario Roederer,Martha Nason,Nancy J. Sullivan,Daniel C. Douek,Barney S. Graham,Robert A. Seder +55 more
TL;DR: In this article, the authors demonstrate how the dose and number of immunizations influence protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization.