Juergen Kast

TL;DR: The data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-Myc in human malignancies and promotes anchorage-independent cell growth and in vivo tumor formation.

TL;DR: Key advantages and limitations to the use of formaldehyde over other cross-linkers and technologies currently used to study protein-protein interactions are highlighted, and formaldehyde-based experimental approaches that are proving very promising in their ability to accurately and efficiently identify novel protein- protein and multiprotein interaction complexes are presented.

TL;DR: A novel method for identifying transient protein‐protein interactions using in vivo cross‐linking and MS‐based protein identification is described and the RasGAP‐related protein IQGAP1 is identified to be a novel interaction partner of M‐RasQ71L.

TL;DR: Formaldehyde cross-linked complexes, precipitated from Jurkat cells or human platelets and analyzed by mass spectrometry, were found to be composed of integrin β 1, α4 and α6 or β1, α6, α2, and α5, respectively.

TL;DR: A fundamental role is defined for aberrant ATF2 transcriptional dysregulation in the etiology of synovial sarcoma through its role as a bridge between activating transcription factor 2 (ATF2) and transducin-like enhancer of split 1 (TLE1).