M
Melissa R. Junttila
Researcher at Genentech
Publications - 68
Citations - 8462
Melissa R. Junttila is an academic researcher from Genentech. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 35, co-authored 60 publications receiving 6966 citations. Previous affiliations of Melissa R. Junttila include University of California, San Francisco & Åbo Akademi University.
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Journal ArticleDOI
Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
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Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
TL;DR: A model proposed in this review places the negative regulation of the ERK pathway in a central position for the cellular decision‐making process that determines whether cells will live or die in response to apoptosis‐promoting signals.
Journal ArticleDOI
CIP2A Inhibits PP2A in Human Malignancies
Melissa R. Junttila,Pietri Puustinen,Minna Niemelä,Minna Niemelä,Raija Ahola,Hugh Arnold,Trine Bøttzauw,Risto Ala-aho,Christina Nielsen,Johanna Ivaska,Johanna Ivaska,Yoichi Taya,Shi-Long Lu,Shujun Lin,Edward K. L. Chan,Xiao-Jing Wang,Reidar Grénman,Reidar Grénman,Juergen Kast,Tuula Kallunki,Rosalie C. Sears,Veli-Matti Kähäri,Veli-Matti Kähäri,Jukka Westermarck,Jukka Westermarck,Jukka Westermarck +25 more
TL;DR: The data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-Myc in human malignancies and promotes anchorage-independent cell growth and in vivo tumor formation.
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Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
Diego O. Croci,Juan P. Cerliani,Tomás Dalotto-Moreno,Santiago P. Méndez-Huergo,Ivan D. Mascanfroni,Sebastián Dergan-Dylon,Marta A. Toscano,Julio J. Caramelo,Juan J. Garcia-Vallejo,Jing Ouyang,Enrique A. Mesri,Melissa R. Junttila,Carlos Bais,Margaret A. Shipp,Mariana Salatino,Gabriel A. Rabinovich,Gabriel A. Rabinovich +16 more
TL;DR: A glycosylation-dependent pathway is identified that compensates for the absence of cognate ligand and preserves angiogenesis in response to VEGF blockade and may increase the efficacy of anti-VEGF treatment.
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Distinct thresholds govern Myc's biological output In vivo
Daniel J. Murphy,Melissa R. Junttila,Laurent Pouyet,Anthony N. Karnezis,Ksenya Shchors,Duyen A. Bui,Lamorna Brown-Swigart,Leisa Johnson,Gerard I. Evan +8 more
TL;DR: It is shown that distinct threshold levels of Myc govern its output in vivo: low levels of deregulated Myc are competent to drive ectopic proliferation of somatic cells and oncogenesis, but activation of the apoptotic and ARF/p53 intrinsic tumor surveillance pathways requires Myc overexpression.