Pietri Puustinen

TL;DR: The data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-Myc in human malignancies and promotes anchorage-independent cell growth and in vivo tumor formation.

TL;DR: Siramesine is identified as a lysosomotropic detergent that triggers cell death via a direct destabilization of lysOSomes and cytoprotection by inducing the accumulation of autophagosomes.

TL;DR: The current picture of signalling pathways connecting mitogenic and stress‐induced signals to the initiation and maturation of autophagosomes are drawn and the possibilities of their targeting as therapeutic adjuvants in anticancer therapy are discussed.

TL;DR: It is shown that methylesterase PME-1-mediated inhibition of the protein phosphatase 2A promotes basal ERK pathway activity and is required for efficient growth factor response and is suggested to have an important functional role in the disease progression of human astrocytic gliomas.

TL;DR: As part of a regulatory loop linking cell metabolism, growth, and proliferation, CIP2A promotes mTORC1-mediated cell growth and autophagy inhibition but is itself down-regulated by autophagic regulation.