J
Julia Alles
Researcher at Saarland University
Publications - 10
Citations - 570
Julia Alles is an academic researcher from Saarland University. The author has contributed to research in topics: microRNA & Gene expression. The author has an hindex of 7, co-authored 10 publications receiving 408 citations.
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Journal ArticleDOI
An estimate of the total number of true human miRNAs.
Julia Alles,Tobias Fehlmann,Ulrike Fischer,Christina Backes,Galata,Marie Minet,Martin Hart,Masood Abu-Halima,Friedrich A. Grässer,Hans-Peter Lenhof,Andreas Keller,Eckart Meese +11 more
TL;DR: The experimentally validated miRNAs will contribute to revising targetomes hypothesized by utilizing falsely annotated miRNA candidates, 1115 of which are currently annotated in miRBase V22.
Journal ArticleDOI
MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma
Wiyada Kwanhian,Wiyada Kwanhian,Dido Lenze,Julia Alles,Natalie Motsch,Stephanie Barth,Celina Döll,Jochen Imig,Michael Hummel,Marianne Tinguely,Pankaj Trivedi,Viraphong Lulitanond,Gunter Meister,Christoph Renner,Friedrich A. Grässer +14 more
TL;DR: The data suggest that the mutations in miR‐142 probably lead to a loss rather than a gain of function, which is the first report describing mutations of a miRNA gene in a large percentage of a distinct lymphoma subtype.
Journal ArticleDOI
MicroRNA Profiling of Epstein-Barr Virus-Associated NK/T-Cell Lymphomas by Deep Sequencing
Natalie Motsch,Julia Alles,Jochen Imig,Jiayun Zhu,Stephanie Barth,Tanja Reineke,Marianne Tinguely,Sergio Cogliatti,Anne Dueck,Gunter Meister,Christoph Renner,Friedrich A. Grässer +11 more
TL;DR: The relevance of deregulated miRNAs for the post-transcriptional gene regulation in nasal NK/T-cell lymphomas is demonstrated and the targets were confirmed by reporter assays and by down-regulation of the proteins by ectopic expression of the cognate miRN
Journal ArticleDOI
A high-resolution map of the human small non-coding transcriptome
Tobias Fehlmann,Christina Backes,Julia Alles,Ulrike Fischer,Martin Hart,Fabian Kern,Hilde Langseth,Trine B. Rounge,Sinan Uğur Umu,Mustafa Kahraman,Thomas Laufer,Jan Haas,Cord F Staehler,Nicole Ludwig,Matthias Hübenthal,Benjamin Meder,Andre Franke,Hans-Peter Lenhof,Eckart Meese,Andreas Keller +19 more
TL;DR: It is determined that 0.8% of the human genome are reliably covered by 874 123 regions with an average length of 31 nt, and among the known small non‐coding RNA classes, microRNAs were the most prevalent.
Journal ArticleDOI
Differential expression of miR-23a/b-3p and its target genes in male patients with subfertility.
Masood Abu-Halima,Basim M. Ayesh,Martin Hart,Julia Alles,Ulrike Fischer,Mohamad Eid Hammadeh,Andreas Keller,Mahmoud Huleihel,Eckart Meese +8 more
TL;DR: This study establishes a link between up-regulation of miR-23a/b-3p and the coincident down- regulation of four expressed genes in the sperm of men with oligoasthenozoospermic men, compared with men with normozoospermia.