Clinical Diagnosis and Management of Breast Cancer
TLDR
The diagnosis and management of breast cancer are undergoing a paradigm shift from a one-size-fits-all approach to an era of personalized medicine, including molecular imaging and genomic expression profiles.Abstract:
The diagnosis and management of breast cancer are undergoing a paradigm shift from a one-size-fits-all approach to an era of personalized medicine. Sophisticated diagnostics, including molecular imaging and genomic expression profiles, enable improved tumor characterization. These diagnostics, combined with newer surgical techniques and radiation therapies, result in a collaborative multidisciplinary approach to minimizing recurrence and reducing treatment-associated morbidity. This article reviews the diagnosis and treatment of breast cancer, including screening, staging, and multidisciplinary management.read more
Citations
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Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast
Bernard Kaye,U. Veronesi +1 more
TL;DR: From these results, mastectomy appears to involve unnecessary mutilation in patients with breast cancer of less than 2 cm and no palpable axillary nodes.
Journal ArticleDOI
Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers
Irina Larionova,Irina Larionova,Gulnara Tuguzbaeva,Anastasia Ponomaryova,Marina N Stakheyeva,Nadezhda V. Cherdyntseva,Nadezhda V. Cherdyntseva,Valentin Pavlov,Evgeniy Choinzonov,Julia Kzhyshkowska,Julia Kzhyshkowska,Julia Kzhyshkowska +11 more
TL;DR: TAMs are highly heterogeneous cells that originate from resident tissue-specific macrophages and from newly recruited monocytes as mentioned in this paper, which constitute up to 50% of the cell mass of human tumors.
Journal ArticleDOI
Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer.
Victor Quereda,Simon Bayle,Francesca Vena,Sylvia M Frydman,Andrii Monastyrskyi,William R. Roush,Derek R. Duckett +6 more
TL;DR: SR-4835 is reported, a highly selective dual inhibitor of CDK12 and CDK13, which disables triple-negative breast cancer (TNBC) cells and provokes a "BRCAness" phenotype that results in deficiencies in DNA damage repair, promoting synergy with DNA-damaging chemotherapy and PARP inhibitors.
Journal ArticleDOI
Beyond breast density: a review on the advancing role of parenchymal texture analysis in breast cancer risk assessment
TL;DR: The advancing role of mammographic texture analysis is reviewed as a potential novel approach to characterize the breast parenchymal tissue to augment conventional density assessment in breast cancer risk estimation.
Journal ArticleDOI
Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer
TL;DR: This review presents an analysis of the role of cfDNA as a liquid biopsy technique and NGS as an analytical tool in studying EGFR and MET, two frequently mutated genes in lung cancer.
References
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Molecular portraits of human breast tumours
Charles M. Perou,Therese Sørlie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,Christian A. Rees,Jonathan R. Pollack,Douglas T. Ross,Hilde Johnsen,Lars A. Akslen,Øystein Fluge,Alexander Pergamenschikov,Cheryl A. Williams,Shirley Zhu,Per Eystein Lønning,Anne Lise Børresen-Dale,Patrick O. Brown,David Botstein +17 more
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