T
Tony N. Marion
Researcher at University of Tennessee Health Science Center
Publications - 73
Citations - 3686
Tony N. Marion is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Antibody & Autoantibody. The author has an hindex of 29, co-authored 67 publications receiving 3430 citations. Previous affiliations of Tony N. Marion include University of Nebraska Medical Center & Yale University.
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Journal ArticleDOI
Naturally occurring dominant resistance mutations to hepatitis c virus protease and polymerase inhibitors in treatment-naive patients
Thomas Kuntzen,Joerg Timm,Andrew Berical,Niall Lennon,Aaron M. Berlin,Sarah Young,Bongshin Lee,David Heckerman,Jonathan M. Carlson,Laura L. Reyor,Marianna Kleyman,Cory M. McMahon,Christopher E. Birch,Julian Schulze zur Wiesch,Timothy Ledlie,Michael Koehrsen,Chinnappa D. Kodira,Andrew Roberts,Georg M. Lauer,Hugo R. Rosen,Florian Bihl,Andreas Cerny,Ulrich Spengler,Zhimin Liu,Arthur Y. Kim,Yanming Xing,Arne Schneidewind,Margaret A. Madey,Jaquelyn Fleckenstein,Vicki M. Park,James E. Galagan,Chad Nusbaum,Bruce D. Walker,Bruce D. Walker,Gerond Lake-Bakaar,Eric S. Daar,Ira M. Jacobson,Edward D. Gomperts,Brian R. Edlin,Sharyne M. Donfield,Raymond T. Chung,Andrew H. Talal,Tony N. Marion,Bruce W. Birren,Matthew R. Henn,Todd M. Allen +45 more
TL;DR: Naturally occurring dominant STAT‐C resistance mutations are common in treatment‐naïve patients infected with HCV genotype 1, and their influence on treatment outcome should be characterized to evaluate possible benefits of drug resistance testing for individual tailoring of drug combinations when treatment options are limited due to previous nonresponse to peginterferon and ribavirin.
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Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.
David F. Smith,William P. Sullivan,Tony N. Marion,Kiyoshi Zaitsu,Benjamin Madden,Daniel J. McCormick,David O. Toft +6 more
TL;DR: Immunoaffinity purification of hsp90 from chick oviduct cytosol reveals two major proteins, hsp70 and a 60-kDa protein (p60), copurifying with hsp 90, which appears to comprise an important functional unit in the assembly of progesterone receptor complexes.
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Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.
TL;DR: The results demonstrate that IgM anti-DNA, like IgG, has the characteristics of a specifically stimulated antibody, and provide a structural explanation for the selective development of IgG antibody to native DNA as autoimmunity to DNA progresses in (NZB x NZW)F1 mice.
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Nucleosomes Are Exposed at the Cell Surface in Apoptosis
TL;DR: The results indicate a direct role for nucleosomes in the execution of apoptosis, clearance of apoptotic cells, and regulation of anti-nuclear autoantibody production in systemic lupus erythematosus.
Journal Article
Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice
TL;DR: Testing the hypothesis that DNA or DNA-protein complexes may provide the antigenic stimulus for autoimmune anti-DNA antibody in normal, nonautoimmune-predisposed mice with complexes formed with DNA and an immunogenic, DNA-binding peptide found it to be applicable to autoimmunity to DNA.