A
Arne Schneidewind
Researcher at Harvard University
Publications - 22
Citations - 3361
Arne Schneidewind is an academic researcher from Harvard University. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 17, co-authored 21 publications receiving 3211 citations. Previous affiliations of Arne Schneidewind include University Hospital Regensburg & Ragon Institute of MGH, MIT and Harvard.
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Journal ArticleDOI
Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
Galit Alter,Maureen P. Martin,Nickolas Teigen,William H. Carr,Todd J. Suscovich,Arne Schneidewind,Hendrik Streeck,Michael S Waring,Angela Meier,Christian Brander,Jeffrey D. Lifson,Todd M. Allen,Mary Carrington,Marcus Altfeld +13 more
TL;DR: The functional ability of NK cells to differentially control HIV-1 replication in vitro based on their KIR and HLA types is examined, providing the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication.
Journal ArticleDOI
Naturally occurring dominant resistance mutations to hepatitis c virus protease and polymerase inhibitors in treatment-naive patients
Thomas Kuntzen,Joerg Timm,Andrew Berical,Niall Lennon,Aaron M. Berlin,Sarah Young,Bongshin Lee,David Heckerman,Jonathan M. Carlson,Laura L. Reyor,Marianna Kleyman,Cory M. McMahon,Christopher E. Birch,Julian Schulze zur Wiesch,Timothy Ledlie,Michael Koehrsen,Chinnappa D. Kodira,Andrew Roberts,Georg M. Lauer,Hugo R. Rosen,Florian Bihl,Andreas Cerny,Ulrich Spengler,Zhimin Liu,Arthur Y. Kim,Yanming Xing,Arne Schneidewind,Margaret A. Madey,Jaquelyn Fleckenstein,Vicki M. Park,James E. Galagan,Chad Nusbaum,Bruce D. Walker,Bruce D. Walker,Gerond Lake-Bakaar,Eric S. Daar,Ira M. Jacobson,Edward D. Gomperts,Brian R. Edlin,Sharyne M. Donfield,Raymond T. Chung,Andrew H. Talal,Tony N. Marion,Bruce W. Birren,Matthew R. Henn,Todd M. Allen +45 more
TL;DR: Naturally occurring dominant STAT‐C resistance mutations are common in treatment‐naïve patients infected with HCV genotype 1, and their influence on treatment outcome should be characterized to evaluate possible benefits of drug resistance testing for individual tailoring of drug combinations when treatment options are limited due to previous nonresponse to peginterferon and ribavirin.
Journal ArticleDOI
HIV-1 adaptation to NK-cell-mediated immune pressure
Galit Alter,David Heckerman,Arne Schneidewind,Lena Fadda,Carl M. Kadie,Jonathan M. Carlson,Cesar Oniangue-Ndza,Maureen P. Martin,Bin Li,Salim I. Khakoo,Mary Carrington,Mary Carrington,Todd M. Allen,Marcus Altfeld +13 more
TL;DR: It is demonstrated that KIR-positive NK cells can place immunological pressure on HIV-1, and that the virus can evade such NK-cell-mediated immune pressure by selecting for sequence polymorphisms, as was previously described for virus-specific T cells and neutralizing antibodies.
Journal ArticleDOI
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.
Arne Schneidewind,Mark A. Brockman,Mark A. Brockman,Ruifeng Yang,Rahma I. Adam,Bin Li,Sylvie Le Gall,Charles R. Rinaldo,Sharon L. Craggs,Rachel L. Allgaier,Karen A. Power,Thomas Kuntzen,Chang-Shung Tung,Montiago X. LaBute,Sandra M. Mueller,Thomas Harrer,Andrew J. McMichael,Philip J. R. Goulder,Christopher Aiken,Christian Brander,Anthony D. Kelleher,Todd M. Allen +21 more
TL;DR: It is concluded that the impact of the R264K substitution on capsid structure constrains viral escape and enables long-term maintenance of the dominant CTL response against B27-KK10, providing an explanation for the protective effect of HLA-B27 during HIV infection.
Journal ArticleDOI
HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition.
Toshiyuki Miura,Mark A. Brockman,Arne Schneidewind,Michael A. Lobritz,Florencia Pereyra,Almas Rathod,Brian L. Block,Zabrina L. Brumme,Chanson J. Brumme,Brett Baker,Alissa C. Rothchild,Bin Li,Alicja Trocha,Alicja Trocha,Emily Cutrell,Nicole Frahm,Christian Brander,Ildiko Toth,Eric J. Arts,Todd M. Allen,Bruce D. Walker,Bruce D. Walker +21 more
TL;DR: A dual mechanism for durable control of HIV replication is suggested, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes.