J
Julie Bouckaert
Researcher at university of lille
Publications - 115
Citations - 4858
Julie Bouckaert is an academic researcher from university of lille. The author has contributed to research in topics: Bacterial adhesin & Escherichia coli. The author has an hindex of 36, co-authored 106 publications receiving 4380 citations. Previous affiliations of Julie Bouckaert include French Institute of Health and Medical Research & Université libre de Bruxelles.
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Journal ArticleDOI
Legume lectin structure.
TL;DR: The quaternary structures of these proteins form the basis of a higher level of specificity, where the spacing between individual epitopes of multivalent carbohydrates becomes important, and is of relevance for their effects on the biological activities of cells such as mitogenic responses.
Journal ArticleDOI
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Julie Bouckaert,Jenny Berglund,Mark A. Schembri,Erwin De Genst,Lieve Cools,Manfred Wuhrer,Chia-Suei Hung,Jerome S. Pinkner,Rikard Slättegård,Anton V. Zavialov,Devapriya Choudhury,Solomon Langermann,Scott J. Hultgren,Lode Wyns,Per Klemm,Stefan Oscarson,Stefan D. Knight,Henri De Greve +17 more
TL;DR: These relative FimH affinities correlate exceptionally well with the relative concentrations of the same glycans needed for the inhibition of adherence of type 1 piliated E. coli.
Journal ArticleDOI
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection
Chia-Suei Hung,Julie Bouckaert,Julie Bouckaert,Danielle Hung,Jerome S. Pinkner,Charlotte Widberg,Anthony DeFusco,C. Gale Auguste,Robert Strouse,Solomon Langermann,Gabriel Waksman,Scott J. Hultgren +11 more
TL;DR: The structure/function analysis demonstrated that the binding of the monosaccharide α‐D‐mannose is the primary bladder cell receptor for uropathogenic E. coli and that this event requires a highly conserved FimH binding pocket.
Journal ArticleDOI
Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex
Adinda Wellens,Corinne K. Garofalo,Hien M. Nguyen,Nani Van Gerven,Rikard Slättegård,Jean-Pierre Hernalsteens,Lode Wyns,Stefan Oscarson,Henri De Greve,Scott J. Hultgren,Julie Bouckaert +10 more
TL;DR: The potential of ligand-based design of antagonists of urinary tract infections is ruled by the structural mimicry of natural epitopes and extends into blocking of bacterial invasion, intracellular growth and capacity to fluxing and of recurrence of the infection.
Journal ArticleDOI
Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding
Swaine L. Chen,Chia S. Hung,Jerome S. Pinkner,Jennifer N. Walker,Corinne K. Cusumano,Zhaoli Li,Julie Bouckaert,Jeffrey I. Gordon,Scott J. Hultgren +8 more
TL;DR: Positive selection analysis of FimH has separated mannose binding from in vivo fitness, suggesting that IBC formation is critical for successful infection of the mammalian bladder, providing support for more general use of in silico positive selection analysis to define the molecular underpinnings of bacterial pathogenesis.