N
Nani Van Gerven
Researcher at Vrije Universiteit Brussel
Publications - 24
Citations - 1378
Nani Van Gerven is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Bacterial adhesin & Protein structure. The author has an hindex of 13, co-authored 24 publications receiving 1065 citations. Previous affiliations of Nani Van Gerven include The Catholic University of America & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG
Parveen Goyal,Petya V. Krasteva,Nani Van Gerven,Francesca Gubellini,Imke Van den Broeck,Anastassia Troupiotis-Tsaïlaki,Wim Jonckheere,Gérard Pehau-Arnaudet,Jerome S. Pinkner,Matthew George Chapman,Scott J. Hultgren,Stefan Howorka,Rémi Fronzes,Han Remaut +13 more
TL;DR: Structural, functional and electrophysiological analyses imply that Escherichia coli CsgG is an ungated, non-selective protein secretion channel that is expected to employ a diffusion-based, entropy-driven transport mechanism.
Journal ArticleDOI
Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex
Adinda Wellens,Corinne K. Garofalo,Hien M. Nguyen,Nani Van Gerven,Rikard Slättegård,Jean-Pierre Hernalsteens,Lode Wyns,Stefan Oscarson,Henri De Greve,Scott J. Hultgren,Julie Bouckaert +10 more
TL;DR: The potential of ligand-based design of antagonists of urinary tract infections is ruled by the structural mimicry of natural epitopes and extends into blocking of bacterial invasion, intracellular growth and capacity to fluxing and of recurrence of the infection.
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Molecular nucleation mechanisms and control strategies for crystal polymorph selection.
Alexander E. S. Van Driessche,Nani Van Gerven,Paul H. H. Bomans,Rick R. M. Joosten,Heiner Friedrich,David Gil-Carton,Nico A. J. M. Sommerdijk,Mike Sleutel +7 more
TL;DR: It is shown that polymorph selection takes place at the earliest stages of structure formation and is based on specific building blocks for each space group, and ways of controlling macromolecular phase transitions are suggested, aiding the development of protein-based drug-delivery systems and macromolescular crystallography.
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Bacterial Amyloid Formation: Structural Insights into Curli Biogensis
TL;DR: The mechanistic insight into the curli assembly pathway will provide tools for new biotechnological applications and inform the design of targeted inhibitors of amyloid polymerization and biofilm formation.
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SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly.
Ekaterina Baranova,Rémi Fronzes,Rémi Fronzes,Abel Garcia-Pino,Nani Van Gerven,David Papapostolou,Gérard Pehau-Arnaudet,Els Pardon,Jan Steyaert,Stefan Howorka,Han Remaut +10 more
TL;DR: The SbsB lattice represents a previously undescribed structural model for protein assemblies and may advance the understanding of SLP physiology and self-assembly, as well as the rational design of engineered higher-order structures for biotechnology.