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Anton V. Zavialov
Researcher at University of Turku
Publications - 44
Citations - 2849
Anton V. Zavialov is an academic researcher from University of Turku. The author has contributed to research in topics: Chaperone (protein) & Protein subunit. The author has an hindex of 21, co-authored 42 publications receiving 2421 citations. Previous affiliations of Anton V. Zavialov include Vrije Universiteit Brussel & Swedish University of Agricultural Sciences.
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Journal ArticleDOI
Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2
Qing Zhou,Dan Yang,Amanda K. Ombrello,Andrey Zavialov,Camilo Toro,Anton V. Zavialov,Deborah L. Stone,Jae Jin Chae,Sergio D. Rosenzweig,Kevin Bishop,Karyl S. Barron,Hye Sun Kuehn,Patrycja Hoffmann,Alejandra Negro,Wanxia L. Tsai,Edward W. Cowen,Wuhong Pei,Joshua D. Milner,Christopher Silvin,Theo Heller,David T. Chin,Nicholas J. Patronas,John S. Barber,Chyi-Chia Richard Lee,Geryl Wood,Alexander Ling,Susan J. Kelly,David E. Kleiner,James C. Mullikin,Nancy J. Ganson,Heidi H. Kong,Sophie Hambleton,Fabio Candotti,Martha Quezado,Katherine R. Calvo,Hawwa Alao,Beverly K. Barham,Anne Jones,James F. Meschia,Bradford B. Worrall,Scott E. Kasner,Stephen S. Rich,Raphaela Goldbach-Mansky,Mario Abinun,Elizabeth Chalom,Alisa Gotte,Marilynn Punaro,Virginia Pascual,James W. Verbsky,Troy R. Torgerson,Nora G. Singer,Timothy R. Gershon,Seza Ozen,Omer Karadag,Thomas A. Fleisher,Elaine F. Remmers,Shawn M. Burgess,Susan Moir,Massimo Gadina,Raman Sood,Michael S. Hershfield,Manfred Boehm,Daniel L. Kastner,Ivona Aksentijevich +63 more
TL;DR: Loss-of-function mutations in CECR1 were associated with a spectrum of vascular and inflammatory phenotypes, ranging from early-onset recurrent stroke to systemic vasculopathy or vasculitis, and were prevented by coinjection with nonmutated (but not with mutated) human C ECR1.
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Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Julie Bouckaert,Jenny Berglund,Mark A. Schembri,Erwin De Genst,Lieve Cools,Manfred Wuhrer,Chia-Suei Hung,Jerome S. Pinkner,Rikard Slättegård,Anton V. Zavialov,Devapriya Choudhury,Solomon Langermann,Scott J. Hultgren,Lode Wyns,Per Klemm,Stefan Oscarson,Stefan D. Knight,Henri De Greve +17 more
TL;DR: These relative FimH affinities correlate exceptionally well with the relative concentrations of the same glycans needed for the inhibition of adherence of type 1 piliated E. coli.
Journal ArticleDOI
Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation.
Anton V. Zavialov,Jenny Berglund,Alexander F Pudney,L.J. Fooks,Tara M Ibrahim,Sheila MacIntyre,Stefan D. Knight +6 more
TL;DR: Genetic data together with high-resolution X-ray structures corresponding to snapshots of the assembly process reveal the structural basis of fiber formation and suggests that the chaperone traps a high-energy folding intermediate of Caf1, which drives fiber formation.
Journal ArticleDOI
Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.
Andrey V. Zavialov,Andrey V. Zavialov,Eduard Gracia,Nicolas Glaichenhaus,Rafael Franco,Anton V. Zavialov,Grégoire Lauvau +6 more
TL;DR: The discovery of the growth factor‐like activity of ADA2 explains clinical observations and suggests that this enzyme could be used as a drug candidate to modulate the immune responses during inflammation and cancer.
Journal ArticleDOI
Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome.
Jens F. Sundström,Alena Vaculova,Andrei Smertenko,Eugene I. Savenkov,Anna Golovko,Elena A. Minina,Budhi Sagar Tiwari,Salvador Rodriguez-Nieto,Andrey A. Zamyatnin,Tuuli Välineva,Juha Saarikettu,Mikko J. Frilander,Maria F. Suarez,Anton V. Zavialov,Ulf Stahl,Patrick J. Hussey,Olli Silvennoinen,Eva Sundberg,Boris Zhivotovsky,Peter V. Bozhkov +19 more
TL;DR: TSN is established as the first biological substrate of metacaspase and demonstrated that despite the divergence of plants and animals from a common ancestor about one billion years ago and their use of distinct PCD pathways, both have retained a common mechanism to compromise cell viability through the cleavage of the same substrate, TSN.