J
Julie Dumont
Researcher at Pasteur Institute
Publications - 42
Citations - 2051
Julie Dumont is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Population & Farnesoid X receptor. The author has an hindex of 23, co-authored 40 publications receiving 1781 citations. Previous affiliations of Julie Dumont include university of lille & University of Rennes.
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Journal ArticleDOI
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
Janne Prawitt,Mouaadh Abdelkarim,Johanna H.M. Stroeve,Iuliana Popescu,Hélène Duez,Vidya Velagapudi,Julie Dumont,Emmanuel Bouchaert,Theo H. van Dijk,F Anthony San Lucas,Emilie Dorchies,Mehdi Daoudi,Sophie Lestavel,Frank J. Gonzalez,Matej Orešič,Bertrand Cariou,Folkert Kuipers,Sandrine Caron,Bart Staels +18 more
TL;DR: Overall, FXR deficiency in obesity beneficially affects body weight development and glucose homeostasis.
Journal ArticleDOI
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies
Rozenn Jossé,Caroline Aninat,Denise Glaise,Julie Dumont,Valérie Fessard,Fabrice Morel,Jean-Michel Poul,Christiane Guguen-Guillouzo,André Guillouzo +8 more
TL;DR: The results bring the first demonstration of long-term stable expression of liver-specific markers in HepaRG hepatocyte cultures maintained at confluence and show that these cells represent a suitable in vitro liver cell model for analysis of acute and chronic toxicity as well as genotoxicity of chemicals in human liver.
Journal ArticleDOI
Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios
Szilvia Bokor,Julie Dumont,Andre Spinneker,Marcela González-Gross,Esther Nova,Kurt Widhalm,George Moschonis,Peter Stehle,Philippe Amouyel,Stefaan De Henauw,Dénes Molnár,Luis A. Moreno,Aline Meirhaeghe,Jean Dallongeville +13 more
TL;DR: It is suggested that rare alleles of several SNPs in the FADS gene cluster are associated with higher D6D activity and lower D5D activity in European adolescents.
Journal ArticleDOI
Oxidative stress plays a major role in chlorpromazine‐induced cholestasis in human HepaRG cells
Sébastien Anthérieu,Sébastien Anthérieu,Pamela Bachour-El Azzi,Pamela Bachour-El Azzi,Pamela Bachour-El Azzi,Julie Dumont,Julie Dumont,Ziad Abdel-Razzak,Christiane Guguen-Guillouzo,Christiane Guguen-Guillouzo,Bernard Fromenty,Bernard Fromenty,Marie-Anne Robin,Marie-Anne Robin,André Guillouzo,André Guillouzo +15 more
TL;DR: Evidence is provided that oxidative stress plays a major role as both a primary causal and an aggravating factor in the early CPZ‐induced intrahepatic cholestasis in human hepatocytes.
Journal ArticleDOI
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.
Sandrine Caron,Carolina Huaman Samanez,Hélène Dehondt,Maheul Ploton,Olivier Briand,Fleur Lien,Emilie Dorchies,Julie Dumont,Catherine Postic,Bertrand Cariou,Philippe Lefebvre,Bart Staels +11 more
TL;DR: FXR transrepresses the expression of genes involved in glycolysis in human hepatocytes, and the underlying molecular mechanisms are unraveled.