C
Catherine Postic
Researcher at University of Paris
Publications - 126
Citations - 13737
Catherine Postic is an academic researcher from University of Paris. The author has contributed to research in topics: Lipogenesis & Insulin resistance. The author has an hindex of 44, co-authored 110 publications receiving 12137 citations. Previous affiliations of Catherine Postic include Vanderbilt University & Vanderbilt University Medical Center.
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Journal ArticleDOI
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
M. Dodson Michael,Rohit N. Kulkarni,Catherine Postic,Steven F. Previs,Gerald I. Shulman,Mark A. Magnuson,C. Ronald Kahn +6 more
TL;DR: In this paper, the Cre-loxP system was used to inactivate the insulin receptor gene in hepatocytes, and the effect of the loss of direct insulin action in liver was investigated.
Journal ArticleDOI
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Catherine Postic,Masakazu Shiota,Kevin D. Niswender,T. L. Jetton,Yeujin Chen,J. M. Moates,Kathy D. Shelton,Jill Lindner,Alan D. Cherrington,Mark A. Magnuson +9 more
TL;DR: These studies indicate that deficiencies in both β cell and hepatic GK contribute to the hyperglycemia of MODY-2, and suggest that heterozygous null for GK, either globally or just in the β cell, survive but are moderately hyperglycemic.
Journal ArticleDOI
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
Rohit N. Kulkarni,Jens C. Brüning,Jonathon N. Winnay,Catherine Postic,Mark A. Magnuson,C R Kahn +5 more
TL;DR: An important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell is indicated and it is suggested that defects in insulin signaling at the level of the beta cell may contribute to the observed alterations in insulin secretion in type 2 diabetes.
Journal ArticleDOI
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
Catherine Postic,Jean Girard +1 more
TL;DR: A review of recent advances in the field of nonalcoholic fatty liver disease discusses recent advances and suggests that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD.
Journal ArticleDOI
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Alexandra Montagner,Arnaud Polizzi,Edwin Fouché,Simon Ducheix,Yannick Lippi,Frédéric Lasserre,Valentin Barquissau,Valentin Barquissau,Marion Régnier,Céline Lukowicz,Fadila Benhamed,Fadila Benhamed,Fadila Benhamed,Alison Iroz,Alison Iroz,Alison Iroz,Justine Bertrand-Michel,Justine Bertrand-Michel,Talal Al Saati,Patricia Cano,Laila Mselli-Lakhal,Gilles Mithieux,Fabienne Rajas,Sandrine Lagarrigue,Sandrine Lagarrigue,Sandrine Lagarrigue,Thierry Pineau,Nicolas Loiseau,Catherine Postic,Catherine Postic,Catherine Postic,Dominique Langin,Dominique Langin,Dominique Langin,Walter Wahli,Walter Wahli,Walter Wahli,Hervé Guillou +37 more
TL;DR: Hepatocyte PPARα deletion impaired fatty acid catabolism, resulting in hepatic lipid accumulation during fasting and in two preclinical models of steatosis, underscore the potential of hepatocyte PParα as a drug target for NAFLD.