Julie E. Horvath

TL;DR: This report provides the first global view of the series of historical events that have reshaped human pericentromeric regions over recent evolutionary time.

TL;DR: A systematic analysis of the evolutionary history of one approximately 700-kb region of 2p11, including the first autosomal transition from pericentromeric sequence to higher-order alpha-satellite DNA, supports a model where duplicative transposition events occurred during a narrow window of evolution after the separation of the human/ape lineage from the Old World monkeys.

TL;DR: These findings resonate with the hypothesis that the serotonin pathway regulates vigilance in primates and by extension provoke the idea that individual variation in vigilance and its underlying biology may be adaptive rather than pathological.

TL;DR: There have been significant changes during primate brain evolution in the components of the glutamatergic signaling pathway in terms of gene expression, protein expression, and promoter sequence changes, which could entail functional modifications in the regulation of specific genes related to processes underlying learning and memory.

TL;DR: Reconstructed primate ancestral XIC sequences show that the most dramatic changes during the past 80 million years occurred between the ancestral primate and the lineage leading to Old World monkeys, and data suggest that evolution of the XIST sequences themselves represents only small lineage-specific changes across the past80 million years.