J
Julie E. Horvath
Researcher at North Carolina Central University
Publications - 37
Citations - 3768
Julie E. Horvath is an academic researcher from North Carolina Central University. The author has contributed to research in topics: Biology & Human genome. The author has an hindex of 18, co-authored 30 publications receiving 3323 citations. Previous affiliations of Julie E. Horvath include North Carolina Museum of Natural Sciences & Case Western Reserve University.
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Journal ArticleDOI
Lessons from the human genome: transitions between euchromatin and heterochromatin
TL;DR: Phylogenetic and comparative studies of pericentromeric sequences suggest that this peculiar genome organization has emerged within the last 30 million years of human evolution and is a source of considerable genomic variation between closely related primate species.
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Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression.
Camille Berthelot,Diego Villar,Julie E. Horvath,Duncan T. Odom,Duncan T. Odom,Paul Flicek,Paul Flicek +6 more
TL;DR: Analysis of promoter and enhancer activity and levels of downstream transcripts in liver samples from 15 mammalian species finds an association between the complexity of the regulatory landscape and the evolutionary stability of gene expression.
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Both noncoding and protein-coding RNAs contribute to gene expression evolution in the primate brain.
Courtney C. Babbitt,Olivier Fedrigo,Adam D. Pfefferle,Alan P. Boyle,Julie E. Horvath,Terrence S. Furey,Gregory A. Wray +6 more
TL;DR: Digital gene expression: tag profiling is used to assess changes in global transcript abundance in the frontal cortex of the brains of 3 humans, 3 chimpanzees, and 3 rhesus macaques and finds that many noncoding transcripts are conserved in both location and expression level between species, suggesting a possible functional role.
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The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences
Cheng Xue,Muthuswamy Raveendran,R. Alan Harris,Gloria L. Fawcett,Gloria L. Fawcett,Xiaoming Liu,Simon D. M. White,Mahmoud Dahdouli,David Rio Deiros,Jennifer E. Below,William J Salerno,Laura A. Cox,Guoping Fan,Betsy Ferguson,Julie E. Horvath,Julie E. Horvath,Julie E. Horvath,Zach Johnson,Zach Johnson,Sreetharan Kanthaswamy,Sreetharan Kanthaswamy,H. Michael Kubisch,Dahai Liu,Michael L. Platt,Michael L. Platt,David Glenn Smith,Binghua Sun,Eric J. Vallender,Feng Wang,Roger W. Wiseman,Rui Chen,Donna M. Muzny,Richard A. Gibbs,Fuli Yu,Jeffrey Rogers +34 more
TL;DR: New insights are provided into the population genomics of nonhuman primates and genomic information directly relevant to primate models of human disease is expanded.
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Genomic Sequence and Transcriptional Profile of the Boundary Between Pericentromeric Satellites and Genes on Human Chromosome Arm 10p
J. Guy,Tom Hearn,Moira Crosier,Jonathan M. Mudge,Luigi Viggiano,Dirk Koczan,Hans Jürgen Thiesen,Jeffrey A. Bailey,Julie E. Horvath,Evan E. Eichler,Mark E. Earthrowl,Panos Deloukas,Lisa French,Jane Rogers,David Bentley,Michael S. Jackson +15 more
TL;DR: It is indicated that recent interchromosomal duplications at this centromere have involved transcriptionally inert, satellite rich DNA, which is likely to be heterochromatic, which suggests that any novel gene structures formed by these inter chromosomal events would require relocation to a more open chromatin environment to be expressed.