Julie Leca

TL;DR: It is reported that hypoxia increases transcription of hexosamine biosynthetic pathway genes as well as levels of O-glycosylated proteins and that O-linked N-acetylglucosaminylation of proteins is a process required for hypoxic pancreatic cancer cell survival.

TL;DR: It is suggested that CAF-tumor cell crosstalk supported by ANXA6+ EVs is predictive of PDA aggressiveness, highlighting a therapeutic target and potential biomarker for PDA.

TL;DR: This study suggests LIF as a candidate serum biomarker and diagnostic tool and a possible therapeutic target for limiting the impact of PANR in PDAC pathophysiology and metastatic progression, and finds that LIF titers positively correlated with intratumoral nerve density.

TL;DR: It is reported that the intratumoral microenvironment is a mediator of PDA-associated neural remodeling (PANR), and factors such as ‘SLIT2’ (an axon guidance molecule), which is expressed by cancer-associated fibroblasts (CAFs), that impact on neuroplastic changes in human PDA.

TL;DR: This study found that loss of transcriptionally active p73 (TAp73), a p53 family member, impacted PDA development and suggested TAp73 as a predictive marker for response to TGF-β inhibitors, which could improve the classification of PDA patients with a view to offering combined therapy involving TGF -β inhibitors.