Orianne Olivares

TL;DR: It is reported that hypoxia increases transcription of hexosamine biosynthetic pathway genes as well as levels of O-glycosylated proteins and that O-linked N-acetylglucosaminylation of proteins is a process required for hypoxic pancreatic cancer cell survival.

TL;DR: E elucidation of the metabolic signature of PDAC has identified the low-density lipoprotein receptor (LDLR), which facilitates cholesterol uptake, as a promising therapeutic target, and identifies LDLR as a novel metabolic target to limit PDAC progression and disease patient relapse.

TL;DR: It is demonstrated that collagen serves as a proline reservoir for PDAC cells to use as a nutrient source when other fuels are limited and that proline oxidase (PRODH1) is required forPDAC cell proliferation in vitro and in vivo.

TL;DR: The need for exploring the impact of metabolites other than glucose and glutamine, such as non‐essential amino acids and oncometabolites, to find new treatments is highlighted to improve the understanding of PDAC biology.