M
Marion Rubis
Researcher at Aix-Marseille University
Publications - 16
Citations - 757
Marion Rubis is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Pancreatic cancer & Adenocarcinoma. The author has an hindex of 6, co-authored 15 publications receiving 493 citations.
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Journal ArticleDOI
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Orianne Olivares,Jared R. Mayers,Victoire Gouirand,Margaret E. Torrence,Tristan Gicquel,Laurence Borge,Sophie Lac,Julie Roques,Marie-Noëlle Lavaut,Patrice Berthezene,Marion Rubis,Véronique Secq,Stéphane Garcia,Vincent Moutardier,Dominique Lombardo,Juan L. Iovanna,Richard Tomasini,Fabienne Guillaumond,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Sophie Vasseur +20 more
TL;DR: It is demonstrated that collagen serves as a proline reservoir for PDAC cells to use as a nutrient source when other fuels are limited and that proline oxidase (PRODH1) is required forPDAC cell proliferation in vitro and in vivo.
Journal ArticleDOI
Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness
Julie Leca,Sébastien Martinez,Sophie Lac,Jérémy Nigri,Véronique Secq,Marion Rubis,Christian Bressy,Arnauld Sergé,Marie-Noëlle Lavaut,Nelson Dusetti,Celine Loncle,Julie Roques,Daniel Pietrasz,Corinne Bousquet,Stéphane Garcia,Samuel Granjeaud,Mehdi Ouaissi,Jean-Baptiste Bachet,Christine Brun,Juan L. Iovanna,Pascale Zimmermann,Sophie Vasseur,Richard Tomasini +22 more
TL;DR: It is suggested that CAF-tumor cell crosstalk supported by ANXA6+ EVs is predictive of PDA aggressiveness, highlighting a therapeutic target and potential biomarker for PDA.
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Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts
Rémy Nicolle,Yuna Blum,Laetitia Marisa,Celine Loncle,Odile Gayet,Vincent Moutardier,Olivier Turrini,Marc Giovannini,Benjamin Bian,Martin Bigonnet,Marion Rubis,Nabila Elarouci,Lucile Armenoult,Mira Ayadi,Pauline Duconseil,Mohamed Gasmi,Mehdi Ouaissi,Aurélie Maignan,Gwen Lomberk,Jean Marie Boher,Jacques Ewald,Erwan Bories,Jonathan Garnier,Anthony Gonçalves,Flora Poizat,Jean-Luc Raoul,Véronique Secq,Stéphane Garcia,Philippe Grandval,Marine Barraud-Blanc,Emmanuelle Norguet,Marine Gilabert,Jean Robert Delpero,Julie Roques,Ezequiel Calvo,Fabienne Guillaumond,Sophie Vasseur,Raul Urrutia,Aurélien de Reyniès,Nelson Dusetti,Juan L. Iovanna +40 more
TL;DR: It is shown that inhibiting NPC1L1 with Ezetimibe, a clinically available drug, might be an efficient approach for treating pancreatic cancers and demonstrate the pivotal role of xenografts for drug discovery and relevance to PDAC.
Journal ArticleDOI
Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.
Benjamin Bian,Martin Bigonnet,Odile Gayet,Celine Loncle,Aurélie Maignan,Marine Gilabert,Vincent Moutardier,Stéphane Garcia,Olivier Turrini,Jean Robert Delpero,Marc Giovannini,Philippe Grandval,Mohamed Gasmi,Mehdi Ouaissi,Véronique Secq,Flora Poizat,Rémy Nicolle,Yuna Blum,Laetitia Marisa,Marion Rubis,Jean-Luc Raoul,James E. Bradner,Jun Qi,Gwen Lomberk,Raul Urrutia,Andrés Saúl,Nelson Dusetti,Juan L. Iovanna +27 more
TL;DR: The results provide new markers and potentially novel therapeutic modalities for distinct subgroups of pancreatic tumors and may find application to the future management of these patients within the setting of individualized medicine clinics.
Journal ArticleDOI
Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer.
Rémy Nicolle,Yuna Blum,Pauline Duconseil,Charles Vanbrugghe,Nicolas Brandone,Flora Poizat,Julie Roques,Martin Bigonnet,Odile Gayet,Marion Rubis,Nabila Elarouci,Lucile Armenoult,Mira Ayadi,Aurélien de Reyniès,Marc Giovannini,Philippe Grandval,Stéphane Garcia,Cindy Canivet,Jérôme Cros,Barbara Bournet,Louis Buscail,Vincent Moutardier,Marine Gilabert,Juan L. Iovanna,Nelson Dusetti +24 more
TL;DR: A PDAC molecular gradient (PAMG) was constructed from PDX transcriptomes recapitulating the five histological groups along a continuous gradient inducing a shift in the actual paradigm of binary classifications towards a better characterization in a gradient.