Véronique Secq

TL;DR: It is demonstrated that collagen serves as a proline reservoir for PDAC cells to use as a nutrient source when other fuels are limited and that proline oxidase (PRODH1) is required forPDAC cell proliferation in vitro and in vivo.

TL;DR: Patient-derived PDAC xenografts are utilized to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival and offering potential new markers and therapeutic targets.

TL;DR: It is suggested that CAF-tumor cell crosstalk supported by ANXA6+ EVs is predictive of PDA aggressiveness, highlighting a therapeutic target and potential biomarker for PDA.

TL;DR: It is shown that inhibiting NPC1L1 with Ezetimibe, a clinically available drug, might be an efficient approach for treating pancreatic cancers and demonstrate the pivotal role of xenografts for drug discovery and relevance to PDAC.

TL;DR: The occurrence of rare coding variants involving TBX4 or FGF10 with the putative hypomorphic non-coding SNVs implies a complex compound inheritance of these pulmonary hypoplasias and supports the importance ofTBX4-FGF10-FGFR2 epithelial-mesenchymal signaling in human lung organogenesis and helps explain the histopathological continuum observed in these rare lethal developmental disorders of the lung.