Sophie Lac

TL;DR: E elucidation of the metabolic signature of PDAC has identified the low-density lipoprotein receptor (LDLR), which facilitates cholesterol uptake, as a promising therapeutic target, and identifies LDLR as a novel metabolic target to limit PDAC progression and disease patient relapse.

TL;DR: It is demonstrated that collagen serves as a proline reservoir for PDAC cells to use as a nutrient source when other fuels are limited and that proline oxidase (PRODH1) is required forPDAC cell proliferation in vitro and in vivo.

TL;DR: It is suggested that CAF-tumor cell crosstalk supported by ANXA6+ EVs is predictive of PDA aggressiveness, highlighting a therapeutic target and potential biomarker for PDA.

TL;DR: It is demonstrated that deficiency of the TAp73 isoform, but not p53 or ΔNp73, leads to male infertility caused by severely impaired germ cell differentiation and maturation to viable sperms in the testes and previously unidentified in vivo evidence that TAp 73 has a unique role in spermatogenesis that ensures the maintenance of mitotic cells and normal spermiogenesis.

TL;DR: It is demonstrated that IL17 induces the expression of REG3β, a well-known mediator of pancreatitis, during acinar-to-ductal metaplasia and in early pancreatic intraepithelial neoplasia (PanIN) lesions and that REG3 β promotes cell growth and decreases sensitivity to cell death through activation of the gp130-JAK2-STAT3-dependent pathway.