J
Julie Lessard
Researcher at Université de Montréal
Publications - 17
Citations - 3591
Julie Lessard is an academic researcher from Université de Montréal. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 11, co-authored 16 publications receiving 3443 citations. Previous affiliations of Julie Lessard include Howard Hughes Medical Institute & Stanford University.
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Journal ArticleDOI
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
Julie Lessard,Guy Sauvageau +1 more
TL;DR: Evidence is provided that the proliferative potential of leukaemic stem and progenitor cells lacking Bmi-1 is compromised because they eventually undergo proliferation arrest and show signs of differentiation and apoptosis, leading to transplant failure of the leukaemia.
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An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development
Julie Lessard,Jiang Wu,Jeffrey A. Ranish,Mimi Wan,Monte M. Winslow,Brett T. Staahl,Hai Wu,Ruedi Aebersold,Isabella A. Graef,Gerald R. Crabtree +9 more
TL;DR: It is suggested that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits by preventing the subunit switch impairs neuronal differentiation.
Journal ArticleDOI
Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes
Jiang Wu,Julie Lessard,Ivan A. Olave,Zilong Qiu,Anirvan Ghosh,Isabella A. Graef,Gerald R. Crabtree,Gerald R. Crabtree +7 more
TL;DR: These studies suggest that the genes encoding the individual subunits of BAF complexes function like letters in a ten-letter word to produce biologically specific meanings (in this case dendritic outgrowth) by combinatorial assembly of their products.
Journal ArticleDOI
Understanding the words of chromatin regulation.
TL;DR: Combinatorial assembly of chromatin regulatory complexes may be critical for maximizing the information content provided by arrays of histone modifications.
Journal ArticleDOI
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation
Julie Lessard,Axel Schumacher,U Thorsteinsdottir,M van Lohuizen,Terry Magnuson,Guy Sauvageau +5 more
TL;DR: Heterozygosity for an eed null allele causes marked myelo- and lymphoproliferative defects, indicating that eed is involved in the negative regulation of the pool size of lymphoid and myeloid progenitor cells.