抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We review the field of cavity optomechanics, which explores the interaction between electromagnetic radiation and nano- or micromechanical motion This review covers the basics of optical cavities and mechanical resonators, their mutual optomechanical interaction mediated by the radiation pressure force, the large variety of experimental systems which exhibit this interaction, optical measurements of mechanical motion, dynamical backaction amplification and cooling, nonlinear dynamics, multimode optomechanics, and proposals for future cavity quantum optomechanics experiments In addition, we describe the perspectives for fundamental quantum physics and for possible applications of optomechanical devices

Cavity Optomechanics

Journal of Statistical Mechanics: theory and experiment

This article reviews recent theoretical and experimental advances in the fundamental understanding and active control of quantum fluids of light in nonlinear optical systems. In the presence of effective photon-photon interactions induced by the optical nonlinearity of the medium, a many-photon system can behave collectively as a quantum fluid with a number of novel features stemming from its intrinsically nonequilibrium nature. A rich variety of recently observed photon hydrodynamical effects is presented, from the superfluid flow around a defect at low speeds, to the appearance of a Mach-Cherenkov cone in a supersonic flow, to the hydrodynamic formation of topological excitations such as quantized vortices and dark solitons at the surface of large impenetrable obstacles. While the review is mostly focused on a specific class of semiconductor systems that have been extensively studied in recent years (planar semiconductor microcavities in the strong light-matter coupling regime having cavity polaritons as elementary excitations), the very concept of quantum fluids of light applies to a broad spectrum of systems, ranging from bulk nonlinear crystals, to atomic clouds embedded in optical fibers and cavities, to photonic crystal cavities, to superconducting quantum circuits based on Josephson junctions. The conclusive part of the article is devoted to a review of the future perspectives in the direction of strongly correlated photon gases and of artificial gauge fields for photons. In particular, several mechanisms to obtain efficient photon blockade are presented, together with their application to the generation of novel quantum phases.

Quantum fluids of light

Microwave photonics with superconducting quantum circuits

What is the complex impedance of a fully coherent quantum resistance-capacitance (RC) circuit at gigahertz frequencies in which a resistor and a capacitor are connected in series? While Kirchhoff's laws predict addition of capacitor and resistor impedances, we report on observation of a different behavior The resistance, here associated with charge relaxation, differs from the usual transport resistance given by the Landauer formula In particular, for a single-mode conductor, the charge-relaxation resistance is half the resistance quantum, regardless of the transmission of the mode The new mesoscopic effect reported here is relevant for the dynamical regime of all quantum devices

https://science.sciencemag.org/content/sci/313/5786/499.full.pdf

Violation of Kirchhoff's Laws for a Coherent RC Circuit

We review the first experiment on dynamic transport in a phase-coherent quantum conductor. In our discussion, we highlight the use of time-dependent transport as a means of gaining insight into charge relaxation on a mesoscopic scale. For this purpose, we studied the ac conductance of a model quantum conductor, i.e. the quantum RC circuit. Prior to our experimental work, Buttiker et al (1993 Phys. Lett. A 180 364–9) first worked on dynamic mesoscopic transport in the 1990s. They predicted that the mesoscopic RC circuit can be described by a quantum capacitance related to the density of states in the capacitor and a constant charge-relaxation resistance equal to half of the resistance quantum h/2e2, when a single mode is transmitted between the capacitance and a reservoir. By applying a microwave excitation to a gate located on top of a coherent submicronic quantum dot that is coupled to a reservoir, we validate this theoretical prediction on the ac conductance of the quantum RC circuit. Our study demonstrates that the ac conductance is directly related to the dwell time of electrons in the capacitor. Thereby, we observed a counterintuitive behavior of a quantum origin: as the transmission of the single conducting mode decreases, the resistance of the quantum RC circuit remains constant while the capacitance oscillates.

/pdf/a-coherent-rc-circuit-3o3hka3ct9.pdf

A coherent RC circuit

We have observed the unconventional photon blockade effect for microwave photons using two coupled superconducting resonators. As opposed to the conventional blockade, only weakly nonlinear resonators are required. The blockade is revealed through measurements of the second order correlation function g^{(2)}(t) of the microwave field inside one of the two resonators. The lowest measured value of g^{(2)}(0) is 0.4 for a resonator population of approximately 10^{-2} photons. The time evolution of g^{(2)}(t) exhibits an oscillatory behavior, which is characteristic of the unconventional photon blockade.

Observation of the Unconventional Photon Blockade in the Microwave Domain

We report the first measurement of the dynamical response of shot noise (measured at frequency omega) of a tunnel junction to an ac excitation at frequency omega0. The experiment is performed in the quantum regime, variant Planck's over 2piomega approximately variant Planck's over 2piomega0>>kBT at very low temperature T=35 mK and high frequency omega0/2pi=6.2 GHz. We observe that the noise responds in phase with the excitation, but not adiabatically. The results are in very good agreement with a prediction based on a new current-current correlator.

Dynamics of Quantum Noise in a Tunnel Junction under ac Excitation

We report on the GHz complex admittance of a chiral one-dimensional ballistic conductor formed by edge states in the quantum Hall regime. The circuit consists of a wide Hall bar (the inductor L) in series with a tunable resistor (R) formed by a quantum point contact. Electron interactions between edges are screened by a pair of side gates. Conductance steps are observed on both real and imaginary parts of the admittance. Remarkably, the phase of the admittance is transmission independent. This shows that the relaxation time of a chiral R -L circuit is resistance independent. A current and charge conserving scattering theory is presented that accounts for this observation with a relaxation time given by the electronic transit time in the circuit.

/pdf/relaxation-time-of-a-chiral-quantum-r-l-circuit-57a86es1l4.pdf

Julien Gabelli

Papers

Violation of Kirchhoff's Laws for a Coherent RC Circuit

A coherent RC circuit

Observation of the Unconventional Photon Blockade in the Microwave Domain

Dynamics of Quantum Noise in a Tunnel Junction under ac Excitation

Relaxation time of a chiral quantum R-L circuit.