M
Maryam Mehrpour
Researcher at Paris Descartes University
Publications - 40
Citations - 5238
Maryam Mehrpour is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Autophagy & Cancer. The author has an hindex of 27, co-authored 40 publications receiving 4424 citations. Previous affiliations of Maryam Mehrpour include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Autophagy and apoptosis dysfunction in neurodegenerative disorders.
Saeid Ghavami,Shahla Shojaei,Behzad Yeganeh,Sudharsana R. Ande,Jaganmohan Reddy Jangamreddy,Maryam Mehrpour,Jonas Christoffersson,Wiem Chaabane,Adel Rezaei Moghadam,Hessam H. Kashani,Mohammad Hashemi,Ali Akbar Owji,Marek J. Łos +12 more
TL;DR: In this article, the authors provide a brief introduction to autophagy and apoptosis pathways focusing on the role of mitochondria and lysosomes, and discuss different ways that autophag and apoptotic modulation may be employed for therapeutic intervention during the maintenance of neurodegenerative disorders.
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CD44 is of Functional Importance for Colorectal Cancer Stem Cells
Lei Du,Hongyi Wang,Leya He,Jingyu Zhang,Biyun Ni,Xiaohui Wang,Haijing Jin,Nathalie Cahuzac,Maryam Mehrpour,Youyong Lu,Quan Chen +10 more
TL;DR: CD44 is a robust marker and is of functional importance for colorectal CSC for cancer initiation and Knockdown of CD44, but not CD133, strongly prevented clonal formation and inhibited tumorigenicity in xenograft model.
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Canonical and non-canonical autophagy: variations on a common theme of self-eating?
TL;DR: Findings suggest that macroautophagy can also occur in the absence of some of these key autophagy proteins, through the unconventional biogenesis of canonical autophagosomes, and such alternatives to the evolutionarily conserved scheme might provide additional therapeutic opportunities.
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Overview of macroautophagy regulation in mammalian cells.
Maryam Mehrpour,Audrey Esclatine,Audrey Esclatine,Isabelle Beau,Isabelle Beau,Patrice Codogno,Patrice Codogno +6 more
TL;DR: The regulation of autophagy is now better understood because of the discovery that the activity of Atg complexes is targeted by protein kinases, and owing to the importance of nuclear regulation via transcription factors in regulating the expression of autophile genes.
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Salinomycin kills cancer stem cells by sequestering iron in lysosomes
Trang Thi Mai,Ahmed Hamaï,Antje Hienzsch,Tatiana Cañeque,Sebastian Müller,Sebastian Müller,Sebastian Müller,Julien Wicinski,Olivier Cabaud,Christine Leroy,Amandine David,Verónica Acevedo,Verónica Acevedo,Verónica Acevedo,Akihide Ryo,Christophe Ginestier,Daniel Birnbaum,Emmanuelle Charafe-Jauffret,Patrice Codogno,Maryam Mehrpour,Raphaël Rodriguez +20 more
TL;DR: Evidence is provided that a synthetic derivative of salinomycin, which is named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by accumulating and sequestering iron in lysosomes.