P
Pascal Finetti
Researcher at Aix-Marseille University
Publications - 67
Citations - 3205
Pascal Finetti is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 21, co-authored 67 publications receiving 2605 citations. Previous affiliations of Pascal Finetti include Centre national de la recherche scientifique.
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Journal ArticleDOI
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Julien Wicinski,Nathalie Cervera,Pascal Finetti,Min-Hee Hur,Mark E. Diebel,Florence Monville,Julie Dutcher,Marthy Brown,Patrice Viens,Luc Xerri,François Bertucci,Giorgio Stassi,Gabriela Dontu,Daniel Birnbaum,Max S. Wicha +17 more
TL;DR: It is shown that ALDEFLUOR-positive cells are responsible for mediating metastasis and the hierarchical organization of immortalized cell lines, establish techniques that can facilitate the characterization of regulatory pathways of CSCs, and identify potential stem cell markers and therapeutic targets.
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A refined molecular taxonomy of breast cancer
Mickaël Guedj,Laetitia Marisa,A. de Reyniès,Béatrice Orsetti,Renaud Schiappa,Frédéric Bibeau,Gaëtan MacGrogan,Florence Lerebours,Pascal Finetti,Michel Longy,Philippe Bertheau,F Bertrand,Françoise Bonnet,Anne-Laure Martin,Jean-Paul Feugeas,Ivan Bièche,Jacqueline Lehmann-Che,Rosette Lidereau,David Jérémie Birnbaum,François Bertucci,Charles Theillet,Charles Theillet +21 more
TL;DR: The data indicate that these six molecular subgroups represent well-defined clinico-biological entities of breast cancer and their identification should facilitate the detection of novel prognostic factors or therapeutical targets in breast cancer.
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H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.
Constance Vennin,Nathalie Spruyt,Fatima Dahmani,Sylvain Julien,François Bertucci,Pascal Finetti,Thierry Chassat,Roland P. Bourette,Xuefen Le Bourhis,Eric Adriaenssens +9 more
TL;DR: It is shown that overexpression of H19/miR-675 enhanced the aggressive phenotype of breast cancer cells including increased cell proliferation and migration in vitro, and increased tumor growth and metastasis in vivo.
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A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.
Anne-Pierre Morel,Anne-Pierre Morel,Christophe Ginestier,Roxane M. Pommier,Roxane M. Pommier,Olivier Cabaud,Emmanuelle Ruiz,Emmanuelle Ruiz,Julien Wicinski,Mojgan Devouassoux-Shisheboran,Mojgan Devouassoux-Shisheboran,Valérie Combaret,Pascal Finetti,Christelle Chassot,Christelle Chassot,Christiane Pinatel,Christiane Pinatel,Frédérique Fauvet,Frédérique Fauvet,Pierre Saintigny,Pierre Saintigny,Emilie Thomas,Caroline Moyret-Lalle,Caroline Moyret-Lalle,Joël Lachuer,Joël Lachuer,Emmanuelle Despras,Jean-Luc Jauffret,François Bertucci,Jérôme Guitton,Anne Wierinckx,Anne Wierinckx,Qing Wang,Nina Radosevic-Robin,Frédérique Penault-Llorca,David G. Cox,David G. Cox,Frédéric Hollande,Stéphane Ansieau,Stéphane Ansieau,Julie Caramel,Julie Caramel,Daniel Birnbaum,Arnaud M. Vigneron,Arnaud M. Vigneron,Agnès Tissier,Agnès Tissier,Emmanuelle Charafe-Jauffret,Alain Puisieux,Alain Puisieux +49 more
TL;DR: It is shown that the differentiation status of normal human mammary epithelial cells dictates cell behavior after an oncogenic event and predetermines the genetic routes toward malignancy, thereby increasing stem cells' intrinsic susceptibility to malignant transformation.
Journal ArticleDOI
miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling
Rita El Helou,Guillaume Pinna,Olivier Cabaud,Julien Wicinski,Ricky Bhajun,Ricky Bhajun,Laurent Guyon,Laurent Guyon,Claire Rioualen,Pascal Finetti,Abigaelle Gros,Bernard Mari,Bernard Mari,Pascal Barbry,Pascal Barbry,François Bertucci,Ghislain Bidaut,Annick Harel-Bellan,Daniel Birnbaum,Emmanuelle Charafe-Jauffret,Christophe Ginestier +20 more
TL;DR: In a series of 120 breast tumors, it is found that a low level of miR-600 is correlated with active WNT signaling and a poor prognosis, highlighting a miR -600-centered signaling network that governs bCSC-fate decisions and influences tumor progression.