J
Julio Aleman
Researcher at Wake Forest Institute for Regenerative Medicine
Publications - 35
Citations - 3488
Julio Aleman is an academic researcher from Wake Forest Institute for Regenerative Medicine. The author has contributed to research in topics: Organ-on-a-chip & 3D bioprinting. The author has an hindex of 19, co-authored 34 publications receiving 2290 citations. Previous affiliations of Julio Aleman include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.
Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Andrea Arneri,Simone Bersini,Su Ryon Shin,Kai Zhu,Zahra Goli-Malekabadi,Julio Aleman,Cristina Colosi,Fabio Busignani,Valeria Dell’Erba,Colin E. Bishop,Thomas Shupe,Danilo Demarchi,Matteo Moretti,Marco Rasponi,Mehmet R. Dokmeci,Anthony Atala,Ali Khademhosseini +19 more
TL;DR: It is demonstrated that the method for generation of endothelialized organoids fabricated through an innovative 3D bioprinting technology may find widespread applications in regenerative medicine, drug screening, and potentially disease modeling.
Journal ArticleDOI
Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
Yu Shrike Zhang,Yu Shrike Zhang,Julio Aleman,Julio Aleman,Julio Aleman,Su Ryon Shin,Su Ryon Shin,Tugba Kilic,Tugba Kilic,Tugba Kilic,Duckjin Kim,Duckjin Kim,Seyed Ali Mousavi Shaegh,Seyed Ali Mousavi Shaegh,Seyed Ali Mousavi Shaegh,Solange Massa,Solange Massa,Solange Massa,Reza Riahi,Reza Riahi,Sukyoung Chae,Sukyoung Chae,Ning Hu,Ning Hu,Ning Hu,Huseyin Avci,Huseyin Avci,Huseyin Avci,Weijia Zhang,Weijia Zhang,Weijia Zhang,Antonia Silvestri,Antonia Silvestri,Antonia Silvestri,Amir Sanati Nezhad,Amir Sanati Nezhad,Amir Sanati Nezhad,Ahmad Manbohi,Ahmad Manbohi,Ahmad Manbohi,Fabio De Ferrari,Fabio De Ferrari,Fabio De Ferrari,Alessandro Polini,Alessandro Polini,Giovanni Calzone,Giovanni Calzone,Noor Shaikh,Noor Shaikh,Noor Shaikh,Parissa Alerasool,Parissa Alerasool,Erica Budina,Erica Budina,Jian Kang,Jian Kang,Nupura S. Bhise,Nupura S. Bhise,João Ribas,João Ribas,João Ribas,Adel Pourmand,Adel Pourmand,Adel Pourmand,Aleksander Skardal,Thomas Shupe,Colin E. Bishop,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Anthony Atala,Ali Khademhosseini +70 more
TL;DR: This work reports a fully integrated modular physical, biochemical, and optical sensing platform, interfaced through a fluidics-routing breadboard with a multi–organ-on-a-chip system to achieve in situ, continual, and automated sensing of microenvironment biophysical and biochemical parameters.
Journal ArticleDOI
3D Bioprinting for Tissue and Organ Fabrication
Yu Shrike Zhang,Yu Shrike Zhang,Kan Yue,Kan Yue,Julio Aleman,Julio Aleman,Kamyar Mollazadeh-Moghaddam,Kamyar Mollazadeh-Moghaddam,Syeda Mahwish Bakht,Syeda Mahwish Bakht,Syeda Mahwish Bakht,Jingzhou Yang,Jingzhou Yang,Jingzhou Yang,Weitao Jia,Weitao Jia,Weitao Jia,Valeria Dell’Erba,Valeria Dell’Erba,Valeria Dell’Erba,Pribpandao Assawes,Pribpandao Assawes,Su Ryon Shin,Su Ryon Shin,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Rahmi Oklu,Ali Khademhosseini +27 more
TL;DR: 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs.
Journal ArticleDOI
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
Aleksander Skardal,Aleksander Skardal,Sean V. Murphy,Mahesh Devarasetty,Mahesh Devarasetty,Ivy Mead,Hyun Wook Kang,Young-Joon Seol,Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Liang Zhao,Julio Aleman,Adam R. Hall,Adam R. Hall,Thomas Shupe,Andre Kleensang,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Sang Jin Lee,Sang Jin Lee,John D. Jackson,James J. Yoo,James J. Yoo,Thomas Hartung,Thomas Hartung,Ali Khademhosseini,Shay Soker,Shay Soker,Colin E. Bishop,Anthony Atala,Anthony Atala +35 more
TL;DR: A three-tissue organ-on-a-chip system, comprised of liver, heart, and lung, is described, and the value of multiple tissue integration for in vitro study of both the efficacy of and side effects associated with candidate drugs is illustrated.
Journal ArticleDOI
From cardiac tissue engineering to heart-on-a-chip: beating challenges.
Yu Shrike Zhang,Julio Aleman,Julio Aleman,Andrea Arneri,Simone Bersini,Francesco Piraino,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Ali Khademhosseini +12 more
TL;DR: Recent advances in engineering cardiac tissues and heart-on-a-chip platforms for their use in heart regeneration and cardiotoxic/cardiotherapeutic drug screening are reviewed, and characterization techniques and personalization potential of the cardiac models are reviewed.