J
Julio Benítez
Researcher at University of Extremadura
Publications - 108
Citations - 4483
Julio Benítez is an academic researcher from University of Extremadura. The author has contributed to research in topics: Debrisoquine & Genotype. The author has an hindex of 40, co-authored 108 publications receiving 4357 citations. Previous affiliations of Julio Benítez include University of Illinois at Urbana–Champaign & Hospital Clínico San Carlos.
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Journal ArticleDOI
Clinically significant pharmacokinetic interactions between dietary caffeine and medications.
TL;DR: Dietary caffeine intake should be considered when planning, or assessing response to, drug therapy, since drugs that are metabolised by, or bind to, the same CYP enzyme have a high potential for pharmacokinetic interactions due to inhibition of drug metabolism.
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Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.
Leif Bertilsson,Juan Antonio Carrillo,Marja-Liisa Dahl,Adrián LLerena,Christina Alm,U Bondesson,L Lindstrom,I Rodriguez de la Rubia,Sara I. Ramos,Julio Benítez +9 more
TL;DR: This study suggests that clozapine is metabolised by CYP1A2 to a major extent and no significant relationships with xanthine oxidase and N-acetyl transferase activity, also assessed by a caffeine test, were found.
Journal ArticleDOI
Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.
Mikael Oscarson,Roman A. McLellan,Harriet Gullstén,José A. G. Agúndez,Julio Benítez,Arja Rautio,Hannu Raunio,Olavi Pelkonen,Magnus Ingelman-Sundberg +8 more
TL;DR: Re‐evaluated the genotyping method used for the CYP2A6*3 allele and found that a gene conversion in the 3′ flanking region of 30–40% of CYP6*1 alleles results in genotype misclassification, implying the presence of numerous defective as well as active CYP1A6/CYP2A7 gene conversion events.
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Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
José A. G. Agúndez,José A. G. Agúndez,María C. Ledesma,María C. Ledesma,José M. Ladero,José M. Ladero,Julio Benítez,Julio Benítez +7 more
TL;DR: The findings indicate that the prevalence of subjects who are carriers of (CYP2D6L)2 is at least as frequent as the prevalenceof poor metabolizers in the population studied.
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Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine.
Juan Antonio Carrillo,Angustias G. Herraiz,Sara I. Ramos,Guillermo Gervasini,Sonia Vizcaino,Julio Benítez +5 more
TL;DR: Smoking-induced increased CYP1A2 activity significantly diminished plasma olanzapine concentrations and the antipsychotic effect of the drug, and such inhibition can contribute to adverse drug interactions.