J
Jun Chen
Researcher at Genentech
Publications - 27
Citations - 1041
Jun Chen is an academic researcher from Genentech. The author has contributed to research in topics: Transient receptor potential channel & Ion channel. The author has an hindex of 13, co-authored 25 publications receiving 828 citations.
Papers
More filters
Journal ArticleDOI
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Jun Chen,Shailen K. Joshi,Stanley Didomenico,Richard J. Perner,Joe Mikusa,Donna M. Gauvin,Jason A. Segreti,Ping Han,Xu-Feng Zhang,Wende Niforatos,Bruce R. Bianchi,Scott J. Baker,Chengmin Zhong,Gricelda H. Simler,Heath A. McDonald,Robert G. Schmidt,Steve McGaraughty,Katharine L. Chu,Connie R. Faltynek,Michael E. Kort,Regina M. Reilly,Philip R. Kym +21 more
TL;DR: A potent, selective, and bioavailable antagonist that attenuates pathological pain without altering noxious cold sensation or body temperature regulation is used to suggest that the selective TRPA1 blockade may present a viable strategy for alleviating pain without untoward side effects.
Journal ArticleDOI
TRPA1 as a drug target—promise and challenges
Jun Chen,David H. Hackos +1 more
TL;DR: The recent progress, unsettled issues, and challenges in TRPA1 research and drug discovery are reviewed.
Journal ArticleDOI
Pore dilation occurs in TRPA1 but not in TRPM8 channels
Jun Chen,Donghee Kim,Bruce R. Bianchi,Eric J. Cavanaugh,Connie R. Faltynek,Philip R. Kym,Regina M. Reilly +6 more
TL;DR: It is shown that TRPV1 activation by reactive or non-reactive agonists induces Yo-Pro uptake, which can be blocked by TRPA1 antagonists, and pore dilation occurs in TRP1, but not in TRPM8 channels.
ComponentDOI
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Hui Xu,Tianbo Li,Alexis Rohou,Christopher P. Arthur,Foteini Tzakoniati,Evera Wong,Alberto Estevez,Christine Kugel,Yvonne Franke,Jun Chen,Claudio Ciferri,David H. Hackos,Christopher M. Koth,Jian Payandeh +13 more
TL;DR: ProTx2 from the Peruvian green velvet tarantula is an inhibitor cystine-knot peptide and selective antagonist of the human Nav1.7 channel, providing a structural framework for activation gating in voltage-gated ion channels.
Journal ArticleDOI
Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
Eugene Y. Chiang,Tianbo Li,Surinder Jeet,Ivan Peng,Juan Zhang,Wyne P. Lee,Jason DeVoss,Patrick Caplazi,Jun Chen,Søren Warming,David H. Hackos,Susmith Mukund,Christopher M. Koth,Jane L. Grogan +13 more
TL;DR: It is shown that Kv1.3 is involved in the development of chronically activated antigen-specific T cells and that T-cell dependency on Kv 1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.