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Tianbo Li
Researcher at Genentech
Publications - 10
Citations - 334
Tianbo Li is an academic researcher from Genentech. The author has contributed to research in topics: Sodium channel & Spider toxin. The author has an hindex of 7, co-authored 10 publications receiving 237 citations.
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ComponentDOI
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Hui Xu,Tianbo Li,Alexis Rohou,Christopher P. Arthur,Foteini Tzakoniati,Evera Wong,Alberto Estevez,Christine Kugel,Yvonne Franke,Jun Chen,Claudio Ciferri,David H. Hackos,Christopher M. Koth,Jian Payandeh +13 more
TL;DR: ProTx2 from the Peruvian green velvet tarantula is an inhibitor cystine-knot peptide and selective antagonist of the human Nav1.7 channel, providing a structural framework for activation gating in voltage-gated ion channels.
Journal ArticleDOI
Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
Eugene Y. Chiang,Tianbo Li,Surinder Jeet,Ivan Peng,Juan Zhang,Wyne P. Lee,Jason DeVoss,Patrick Caplazi,Jun Chen,Søren Warming,David H. Hackos,Susmith Mukund,Christopher M. Koth,Jane L. Grogan +13 more
TL;DR: It is shown that Kv1.3 is involved in the development of chronically activated antigen-specific T cells and that T-cell dependency on Kv 1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.
Journal ArticleDOI
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel
Chang Liu,Rebecca M. Reese,Simon Vu,Lionel Rouge,Shannon D. Shields,Satoko Kakiuchi-Kiyota,Huifen Chen,Kevin M. Johnson,Yu Patrick Shi,Tania Chernov-Rogan,Demi Maria Zabala Greiner,Pawan Bir Kohli,David H. Hackos,Bobby Brillantes,Christine Tam,Tianbo Li,Jianyong Wang,Brian Safina,Steve Magnuson,Matthew Volgraf,Jian Payandeh,Jie Zheng,Alexis Rohou,Jun Chen +23 more
TL;DR: The discovery of a non-covalent agonist, GNE551, is reported, and a cryo-EM structure of the TRPA1-GNE551 complex is determined, revealing a distinct binding pocket and ligand-interaction mechanism.
Journal ArticleDOI
High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE.
TL;DR: SyncroPatch 768PE is utilized, one of the latest generation APC platforms which conducts parallel recording from two-384 modules with giga-seal data quality, to push the boundaries of patch clamp electrophysiology and is suggested to provide a powerful platform for ion channel research and drug discovery.
Journal ArticleDOI
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors
Tania Chernov-Rogan,Tianbo Li,Gang Lu,Henry Verschoof,Kuldip Khakh,Steven W. Jones,Maureen Beresini,Chang Liu,Daniel F. Ortwine,Steven J. McKerrall,David H. Hackos,Daniel P. Sutherlin,Charles J. Cohen,Jun Chen +13 more
TL;DR: It is shown that this assay is biased toward nonselective pore blockers and fails to detect the most potent, selective voltage-sensing domain 4 (VSD4) blockers, including PF-05089771 (PF-771) and GX-936.