J
Jun Gao
Researcher at Picower Institute for Learning and Memory
Publications - 15
Citations - 2977
Jun Gao is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Medicine & Neurodegeneration. The author has an hindex of 7, co-authored 11 publications receiving 2675 citations. Previous affiliations of Jun Gao include Massachusetts Institute of Technology & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
HDAC2 negatively regulates memory formation and synaptic plasticity
Ji-Song Guan,Stephen J. Haggarty,Emanuela Giacometti,Jan Hermen Dannenberg,Jan Hermen Dannenberg,Nadine F. Joseph,Nadine F. Joseph,Jun Gao,Thomas J.F. Nieland,Ying Zhou,X. L. Wang,Ralph Mazitschek,James E. Bradner,Ronald A. DePinho,Rudolf Jaenisch,Li-Huei Tsai,Li-Huei Tsai +16 more
TL;DR: It is suggested that HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory.
Journal ArticleDOI
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Jun Gao,Wenyuan Wang,Wenyuan Wang,Yingwei Mao,Yingwei Mao,Johannes Gräff,Johannes Gräff,Ji-Song Guan,Ji-Song Guan,Ling Pan,Ling Pan,Gloria Mak,Gloria Mak,Dohoon Kim,Dohoon Kim,Susan C. Su,Susan C. Su,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +19 more
TL;DR: It is reported that SIRT1 modulates synaptic plasticity and memory formation via a microRNA-mediated mechanism and is demonstrated as a potential therapeutic target for the treatment of central nervous system disorders.
Journal ArticleDOI
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Matthew M. Dobbin,Ram Madabhushi,Ling Pan,Yue Chen,Dohoon Kim,Jun Gao,Jun Gao,Biafra Ahanonu,Ping-Chieh Pao,Yi Qiu,Yingming Zhao,Li-Huei Tsai +11 more
TL;DR: It is proposed that Sirt1 is an apical transducer of the DSB response and that SIRT1 activation offers an important therapeutic avenue in neurodegeneration.
Journal ArticleDOI
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
Bjoern Schwer,Bjoern Schumacher,David B. Lombard,Cuiying Xiao,Martin V. Kurtev,Jun Gao,Jennifer I. Schneider,Hua Chai,Roderick T. Bronson,Li-Huei Tsai,Li-Huei Tsai,Chu-Xia Deng,Frederick W. Alt +12 more
TL;DR: It is proposed that Sirt6 functions as a central regulator of somatic growth and plays an important role in preventing obesity by modulating neural chromatin structure and gene activity.
Journal ArticleDOI
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
Johannes Gräff,M C Kahn,Alireza Samiei,Jun Gao,Kristie T. Ota,Damien Rei,Damien Rei,Li-Huei Tsai,Li-Huei Tsai +8 more
TL;DR: It is found that oral administration of a SIRT1-activating compound essentially replicated the beneficial effects of CR and might provide a pharmacological alternative to the regimen of CR against neurodegeneration and its associated ailments.